192 entries « 3 of 4 »

2018

Hughes, Michael P; Sawaya, Michael R; Boyer, David R; Goldschmidt, Lukasz; Rodriguez, Jose A; Cascio, Duilio; Chong, Lisa; Gonen, Tamir; Eisenberg, David S

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks

In: Science, vol. 359, no. 6376, pp. 698–701, 2018.

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Nannenga, Brent L; Gonen, Tamir

MicroED: a versatile cryoEM method for structure determination

In: Emerg Top Life Sci, vol. 2, no. 1, pp. 1–8, 2018.

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Hattne, Johan; Shi, Dan; Glynn, Calina; Zee, Chih-Te; Gallagher-Jones, Marcus; Martynowycz, Michael W.; Rodriguez, Jose A.; Gonen, Tamir

Analysis of global and site-specific radiation damage in cryo-EM

bioRxiv, 2018.

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Gallagher-Jones, Marcus; Glynn, Calina; Boyer, David R; Martynowycz, Michael W; Hernandez, Evelyn; Miao, Jennifer; Zee, Chih-Te; Novikova, Irina V; Goldschmidt, Lukasz; McFarlane, Heather T; Helguera, Gustavo F; Evans, James E; Sawaya, Michael R; Cascio, Duilio; Eisenberg, David S; Gonen, Tamir; Rodriguez, Jose A

Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp

In: Nat. Struct. Mol. Biol., vol. 25, no. 2, pp. 131–134, 2018.

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2017

Purdy, Michael D.; Shi, Dan; Chrustowicz, Jakub; Hattne, Johan; Gonen, Tamir; Yeager, Mark

MicroED Structures of HIV-1 Gag CTD-SP1 Reveal Binding Interactions with the Maturation Inhibitor Bevirimat

bioRxiv, 2017.

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Seidler, P M; Boyer, D R; Rodriguez, J A; Sawaya, M R; Cascio, D; Murray, K; Gonen, T; Eisenberg, D S

Structure-based inhibitors of tau aggregation

In: Nat Chem, vol. 10, no. 2, pp. 170–176, 2017.

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Liu, Yuxi; Gonen, Shane; Gonen, Tamir; Yeates, Todd O.

Near-Atomic Cryo-EM Imaging of a Small Protein Displayed on a Designed Scaffolding System

bioRxiv, 2017.

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Vergara, Sandra; Lukes, Dylan A; Martynowycz, Michael W; Santiago, Ulises; Plascencia-Villa, Germán; Weiss, Simon C; de la Cruz, Jason M; Black, David M; Alvarez, Marcos M; López-Lozano, Xochitl; Barnes, Christopher O; Lin, Guowu; Weissker, Hans-Christian; Whetten, Robert L; Gonen, Tamir; Yacaman, Miguel Jose; Calero, Guillermo

MicroED Structure of Au₁₄₆(p-MBA)₅₇ at Subatomic Resolution Reveals a Twinned FCC Cluster

In: J Phys Chem Lett, vol. 8, no. 22, pp. 5523–5530, 2017.

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Gonen, Tamir; Rodriguez, Jose; Schlichting, Ilme (Ed.)

Challenges in Structural Biology

HHMI Janelia Research Campus, Janelia Research Campus, 2017, (Conference held 2017-10-15 to 2015-10-18 at Janelia Research Campus).

Rodriguez, Jose A; Eisenberg, David S; Gonen, Tamir

Taking the measure of MicroED

In: Curr. Opin. Struct. Biol., vol. 46, pp. 79–86, 2017.

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Wright, Zoë V F; McCarthy, Stephen; Dickman, Rachel; Reyes, Francis E; Sanchez-Martinez, Silvia; Cryar, Adam; Kilford, Iian; Hall, Adrian; Takle, Andrew K; Topf, Maya; Gonen, Tamir; Thalassinos, Konstantinos; Tabor, Alethea B

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Naᵥ1.7

In: J. Am. Chem. Soc., vol. 139, no. 37, pp. 13063–13075, 2017.

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Hughes, Michael P.; Sawaya, Michael R.; Goldschmidt, Lukasz; Rodriguez, Jose A.; Cascio, Duilio; Gonen, Tamir; Eisenberg, David S.

Low-complexity domains adhere by reversible amyloid-like interactions between kinked β-sheets

bioRxiv, 2017.

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de la Cruz, M. Jason; Martynowycz, Michael; Hattne, Johan; Shi, Dan; Gonen, Tamir

A method to minimize condenser lens-induced hysteresis effects in a JEOL JEM-3200FSC microscope to enable stable cryoEM low-dose operations

bioRxiv 2017.

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Martynowycz, Michael W.; Glynn, Calina; Miao, Jennifer; de la Cruz, M. Jason; Hattne, Johan; Shi, Dan; Cascio, Duilio; Rodriguez, Jose; Gonen, Tamir

MicroED Structures from Micrometer Thick Protein Crystals

bioRxiv, 2017.

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de la Cruz, M. Jason; Hattne, Johan; Shi, Dan; Rodriguez, Jose A.; Reyes, Francis E.; Gonen, Tamir

Micro- and nanocrystal preparation for MicroED and XFEL serial crystallography by fragmentation of imperfect crystals

Nature Protocol Exchange 2017.

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de la Cruz, Jason M; Hattne, Johan; Shi, Dan; Seidler, Paul; Rodriguez, Jose; Reyes, Francis E; Sawaya, Michael R; Cascio, Duilio; Weiss, Simon C; Kim, Sun Kyung; Hinck, Cynthia S; Hinck, Andrew P; Calero, Guillermo; Eisenberg, David; Gonen, Tamir

Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED

In: Nat. Methods, vol. 14, no. 4, pp. 399–402, 2017.

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Krotee, Pascal; Rodriguez, Jose A; Sawaya, Michael R; Cascio, Duilio; Reyes, Francis E; Shi, Dan; Hattne, Johan; Nannenga, Brent L; Oskarsson, Marie E; Philipp, Stephan; Griner, Sarah; Jiang, Lin; Glabe, Charles G; Westermark, Gunilla T; Gonen, Tamir; Eisenberg, David S

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

In: Elife, vol. 6, 2017.

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2016

Nannenga, Brent L; Gonen, Tamir

MicroED opens a new era for biological structure determination

In: Curr. Opin. Struct. Biol., vol. 40, pp. 128–135, 2016.

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Sawaya, Michael R; Rodriguez, Jose; Cascio, Duilio; Collazo, Michael J; Shi, Dan; Reyes, Francis E; Hattne, Johan; Gonen, Tamir; Eisenberg, David S

Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED

In: Proc. Natl. Acad. Sci. U.S.A., vol. 113, no. 40, pp. 11232–11236, 2016.

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Liu, Shian; Hattne, Johan; Reyes, Francis E; Sanchez-Martinez, Silvia; de la Cruz, Jason M; Shi, Dan; Gonen, Tamir

Atomic resolution structure determination by the cryo-EM method MicroED

In: Protein Sci., vol. 26, no. 1, pp. 8–15, 2016.

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Bale, Jacob B; Gonen, Shane; Liu, Yuxi; Sheffler, William; Ellis, Daniel; Thomas, Chantz; Cascio, Duilio; Yeates, Todd O; Gonen, Tamir; King, Neil P; Baker, David

Accurate design of megadalton-scale two-component icosahedral protein complexes

In: Science, vol. 353, no. 6297, pp. 389–394, 2016.

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Hsia, Yang; Bale, Jacob B; Gonen, Shane; Shi, Dan; Sheffler, William; Fong, Kimberly K; Nattermann, Una; Xu, Chunfu; Huang, Po‐Ssu.; Ravichandran, Rashmi; Yi, Sue; Davis, Trisha N; Gonen, Tamir; King, Neil P; Baker, David

Design of a hyperstable 60-subunit protein icosahedron

In: Nature, vol. 535, no. 7610, pp. 136–139, 2016.

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Hattne, Johan; Shi, Dan; de la Cruz, Jason M; Reyes, Francis E; Gonen, Tamir

Modeling truncated pixel values of faint reflections in MicroED images

In: J Appl Crystallogr, vol. 49, no. Pt 3, pp. 1029–1034, 2016.

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Shi, Dan; Nannenga, Brent L; de la Cruz, Jason M; Liu, Jinyang; Sawtelle, Steven; Calero, Guillermo; Reyes, Francis E; Hattne, Johan; Gonen, Tamir

The collection of MicroED data for macromolecular crystallography

In: Nat Protoc, vol. 11, no. 5, pp. 895–904, 2016.

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Meyer, Peter A; Socias, Stephanie; Key, Jason; Ransey, Elizabeth; Tjon, Emily C; Buschiazzo, Alejandro; Lei, Ming; Botka, Chris; Withrow, James; Neau, David; Rajashankar, Kanagalaghatta; Anderson, Karen S; Baxter, Richard H; Blacklow, Stephen C; Boggon, Titus J; Bonvin, Alexandre M J J; Borek, Dominika; Brett, Tom J; Caflisch, Amedeo; Chang, Chung-I; Chazin, Walter J; Corbett, Kevin D; Cosgrove, Michael S; Crosson, Sean; Dhe‐Paganon, Sirano; Cera, Enrico Di; Drennan, Catherine L; Eck, Michael J; Eichman, Brandt F; Fan, Qing R; Ferré‐D’Ámaré, Adrian R; Fromme, Christopher J; Garcia, Christopher K; Gaudet, Rachelle; Gong, Peng; Harrison, Stephen C; Heldwein, Ekaterina E; Jia, Zongchao; Keenan, Robert J; Kruse, Andrew C; Kvansakul, Marc; McLellan, Jason S; Modis, Yorgo; Nam, Yunsun; Otwinowski, Zbyszek; Pai, Emil F; Pereira, Pedro José Barbosa; Petosa, Carlo; Raman, C S; Rapoport, Tom A; Roll‐Mecak, Antonina; Rosen, Michael K; Rudenko, Gabby; Schlessinger, Joseph; Schwartz, Thomas U; Shamoo, Yousif; Sondermann, Holger; Tao, Yizhi J; Tolia, Niraj H; Tsodikov, Oleg V; Westover, Kenneth D; Wu, Hao; Foster, Ian; Fraser, James S; Maia, Felipe R N C; Gonen, Tamir; Kirchhausen, Tom; Diederichs, Kay; Crosas, Mercè; Sliz, Piotr

Data publication with the structural biology data grid supports live analysis

In: Nat Commun, vol. 7, pp. 10882, 2016.

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Rodriguez, J A; Gonen, T

High-Resolution Macromolecular Structure Determination by MicroED, a cryo-EM Method

In: Methods in Enzymology, vol. 579, Chapter 14, pp. 369–392, 2016.

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2015

Rodriguez, Jose A; Ivanova, Magdalena I; Sawaya, Michael R; Cascio, Duilio; Reyes, Francis E; Shi, Dan; Sangwan, Smriti; Guenther, Elizabeth L; Johnson, Lisa M; Zhang, Meng; Jiang, Lin; Arbing, Mark A; Nannenga, Brent L; Hattne, Johan; Whitelegge, Julian; Brewster, Aaron S; Messerschmidt, Marc; Boutet, Sébastien; Sauter, Nicholas K; Gonen, Tamir; Eisenberg, David S

Structure of the toxic core of α-synuclein from invisible crystals

In: Nature, vol. 525, no. 7570, pp. 486–490, 2015.

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Bale, Jacob B; Park, Rachel U; Liu, Yuxi; Gonen, Shane; Gonen, Tamir; Cascio, Duilio; King, Neil P; Yeates, Todd O; Baker, David

Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression

In: Protein Sci., vol. 24, no. 10, pp. 1695–1701, 2015.

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Hattne, Johan; Reyes, Francis E; Nannenga, Brent L; Shi, Dan; de la Cruz, Jason M; Leslie, Andrew G W; Gonen, Tamir

MicroED data collection and processing

In: Acta Crystallogr A Found Adv, vol. 71, no. Pt 4, pp. 353–360, 2015.

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Gonen, Shane; DiMaio, Frank; Gonen, Tamir; Baker, David

Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces

In: Science, vol. 348, no. 6241, pp. 1365–1368, 2015.

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2014

Huang, Po-Ssu; Oberdorfer, Gustav; Xu, Chunfu; Pei, Xue Y; Nannenga, Brent L; Rogers, Joseph M; DiMaio, Frank; Gonen, Tamir; Luisi, Ben; Baker, David

High thermodynamic stability of parametrically designed helical bundles

In: Science, vol. 346, no. 6208, pp. 481–485, 2014.

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Nannenga, Brent L; Shi, Dan; Hattne, Johan; Reyes, Francis E; Gonen, Tamir

Structure of catalase determined by MicroED

In: Elife, vol. 3, pp. e03600, 2014.

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Russell, Alistair B; Wexler, Aaron G; Harding, Brittany N; Whitney, John C; Bohn, Alan J; Goo, Young Ah; Tran, Bao Q; Barry, Natasha A; Zheng, Hongjin; Peterson, Brook S; Chou, Seemay; Gonen, Tamir; Goodlett, David R; Goodman, Andrew L; Mougous, Joseph D

A type VI Secretion-Related Pathway in Bacteroidetes Mediates Interbacterial Antagonism

In: Cell Host Microbe, vol. 16, no. 2, pp. 227–236, 2014.

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Wisedchaisri, Goragot; Park, Min-Sun; Iadanza, Matthew G; Zheng, Hongjin; Gonen, Tamir

Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE

In: Nat Commun, vol. 5, pp. 4521, 2014.

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Nannenga, Brent L; Shi, Dan; Leslie, Andrew G W; Gonen, Tamir

High-resolution structure determination by continuous-rotation data collection in MicroED

In: Nat. Methods, vol. 11, no. 9, pp. 927–930, 2014.

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Nannenga, Brent L; Gonen, Tamir

Protein structure determination by MicroED

In: Curr. Opin. Struct. Biol., vol. 27, pp. 24–31, 2014.

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Gonen, Tamir; Waksman, Gabriel

Editorial overview: Membranes: recent methods in the study of membrane protein structure

In: Curr. Opin. Struct. Biol., vol. 27, pp. iv-v, 2014.

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Iadanza, Matthew G; Gonen, Tamir

A suite of software for processing MicroED data of extremely small protein crystals

In: J Appl Crystallogr, vol. 47, no. Pt 3, pp. 1140–1145, 2014.

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King, Neil P; Bale, Jacob B; Sheffler, William; McNamara, Dan E; Gonen, Shane; Gonen, Tamir; Yeates, Todd O; Baker, David

Accurate design of co-assembling multi-component protein nanomaterials

In: Nature, vol. 510, no. 7503, pp. 103–108, 2014.

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Anderson, Thomas M.; Clay, Mary C.; Cioffi, Alexander G.; Diaz, Katrina A.; Hisao, Grant S.; Tuttle, Marcus D.; Nieuwkoop, Andrew J.; Comellas, Gemma; Maryum, Nashrah; Wang, Shu; Uno, Brice E.; Wildeman, Erin L.; Gonen, Tamir; Rienstra, Chad M.; Burke, Martin D.

Amphotericin forms an extramembranous and fungicidal sterol sponge

In: Nat. Chem. Biol., vol. 10, no. 5, pp. 400–406, 2014.

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2013

Shi, Dan; Nannenga, Brent L; Iadanza, Matthew G; Gonen, Tamir

Three-dimensional electron crystallography of protein microcrystals

In: Elife, vol. 2, pp. e01345, 2013.

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Smith, Donelson F; Reichow, Steve L; Esseltine, Jessica L; Shi, Dan; Langeberg, Lorene K; Scott, John D; Gonen, Tamir

Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation

In: Elife, vol. 2, pp. e01319, 2013.

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Gold, Matthew G; Gonen, Tamir; Scott, John D

Local cAMP signaling in disease at a glance

In: J. Cell. Sci., vol. 126, no. Pt 20, pp. 4537–4543, 2013.

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Reichow, Stephen; Gonen, Tamir

Dynamic Modulation of Water Permeability in the Lens Aquaporin-0

In: Proceedings of Microscopy & Microanalysis, pp. 50–51, 2013.

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Silverman, Julie M; Agnello, Danielle M; Zheng, Hongjin; Andrews, Benjamin T; Li, Mo; Catalano, Carlos E; Gonen, Tamir; Mougous, Joseph D

Haemolysin Coregulated Protein Is an Exported Receptor and Chaperone of Type VI Secretion Substrates

In: Mol. Cell, vol. 51, no. 5, pp. 584–593, 2013.

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Reichow, Steve L; Clemens, Daniel M; Freites, Alfredo J; Nemeth-Cahalan, Karin L; Heyden, Matthias; Tobias, Douglas J; Hall, James E; Gonen, Tamir

Allosteric mechanism of water-channel gating by Ca²⁺-calmodulin

In: Nat. Struct. Mol. Biol., vol. 20, no. 9, pp. 1085–1092, 2013.

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Zheng, Hongjin; Wisedchaisri, Goragot; Gonen, Tamir

Crystal structure of a nitrate/nitrite exchanger

In: Nature, vol. 497, no. 7451, pp. 647–651, 2013.

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Nannenga, Brent L; Iadanza, Matthew G; Vollmar, Breanna S; Gonen, Tamir

Overview of Electron Crystallography of Membrane Proteins: Crystallization and Screening Strategies Using Negative Stain Electron Microscopy

In: Curr Protoc Protein Sci, vol. 72, no. 1, pp. 17.15.1–17.15.11, 2013.

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Shi, Liang; Zheng, Hongjin; Zheng, Hui; Borkowski, Brian A; Shi, Dan; Gonen, Tamir; Jiang, Qiu-Xing

Voltage sensor ring in a native structure of a membrane-embedded potassium channel

In: Proc. Natl. Acad. Sci. U.S.A., vol. 110, no. 9, pp. 3369–3374, 2013, (Retracted).

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2012

Filbin, Megan E; Vollmar, Breanna S; Shi, Dan; Gonen, Tamir; Kieft, Jeffrey S

HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation

In: Nat. Struct. Mol. Biol., vol. 20, no. 2, pp. 150–158, 2012.

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192 entries « 3 of 4 »