131 entries « 1 of 3 »

2022

Porter, Nicholas J; Danelius, Emma; Gonen, Tamir; Arnold, Frances H

Biocatalytic Carbene Transfer Using Diazirines Journal Article

In: J Am Chem Soc, 2022, ISSN: 1520-5126.

Abstract | Links | Altmetric

Clabbers, Max T B; Shiriaeva, Anna; Gonen, Tamir

MicroED: conception, practice and future opportunities Journal Article

In: IUCrJ, vol. 9, no. Pt 2, pp. 169–179, 2022, ISSN: 2052-2525.

Abstract | Links | Altmetric

Gallenito, Marc J; Gonen, Tamir

Studying membrane proteins with MicroED Journal Article

In: Biochem Soc Trans, vol. 50, no. 1, pp. 231–239, 2022, ISSN: 1470-8752.

Abstract | Links | Altmetric

2021

Martynowycz, Michael W; Clabbers, Max T B; Unge, Johan; Hattne, Johan; Gonen, Tamir

Benchmarking the ideal sample thickness in cryo-EM Journal Article

In: Proc Natl Acad Sci U S A, vol. 118, no. 49, 2021, ISSN: 1091-6490.

Abstract | Links | Altmetric

Clark, Lisa J.; Bu, Guanhong; Nannenga, Brent L.; Gonen, Tamir

MicroED for the study of protein–ligand interactions and the potential for drug discovery Journal Article

In: Nat Rev Chem, vol. 5, pp. 853–858, 2021.

Abstract | Links | Altmetric

Martynowycz, Michael W; Gonen, Tamir

Protocol for the use of focused ion-beam milling to prepare crystalline lamellae for microcrystal electron diffraction (MicroED) Journal Article

In: STAR Protoc, vol. 2, no. 3, pp. 100686, 2021, ISSN: 2666-1667.

Abstract | Links | Altmetric

Martynowycz, Michael W.; Shiriaeva, Anna; Ge, Xuanrui; Hattne, Johan; Nannenga, Brent L.; Cherezov, Vadim; Gonen, Tamir

MicroED structure of the human adenosine receptor determined from a single nanocrystal in LCP Journal Article

In: Proc Natl Acad Sci U S A, vol. 118, no. 36, pp. e2106041118, 2021.

Abstract | Links | Altmetric

Mu, Xuelang; Gillman, Cody; Nguyen, Chi; Gonen, Tamir

An Overview of Microcrystal Electron Diffraction (MicroED) Journal Article

In: Annu Rev Biochem, vol. 90, pp. 431–450, 2021, ISSN: 1545-4509.

Abstract | Links | Altmetric

Lei, Hsiang-Ting; Mu, Xuelang; Hattne, Johan; Gonen, Tamir

A conformational change in the N Terminus of SLC38A9 signals mTORC1 activation Journal Article

In: Structure, vol. 29, no. 5, pp. 426–432.e8, 2021.

Abstract | Links | Altmetric

Danelius, E; Gonen, T

Protein and Small Molecule Structure Determination by the Cryo-EM Method MicroED Book Chapter

In: Owens, Raymond J. (Ed.): vol. 2305, pp. 323–342, 2021.

Abstract | Links | Altmetric

Martynowycz, M W; Gonen, T

Studying Membrane Protein Structures by MicroED Book Chapter

In: Schmidt-Krey, Ingeborg; Gumbart, James C. (Ed.): vol. 2302, pp. 137–151, 2021.

Abstract | Links | Altmetric

Martynowycz, M W; Gonen, T

Microcrystal Electron Diffraction of Small Molecules Journal Article

In: J Vis Exp, no. 169, 2021.

Abstract | Links | Altmetric

Danelius, E; Halaby, S; van der Donk, W A; Gonen, T

MicroED in natural product and small molecule research Journal Article

In: Nat Prod Rep, vol. 38, no. 3, 2021.

Abstract | Links | Altmetric

Halaby, Steve; Martynowycz, Michael W.; Zhu, Ziyue; Tretiak, Sergei; Zhugayevych, Andriy; Gonen, Tamir; and Martin Seifrid,

Microcrystal Electron Diffraction for Molecular Design of Functional Non-Fullerene Acceptor Structures Journal Article

In: Chem. Mater., vol. 33, no. 3, pp. 966–977, 2021.

Abstract | Links | Altmetric

Martynowycz, Michael W.; Gonen, Tamir

Ligand Incorporation into Protein Microcrystals for MicroED by On-Grid Soaking Journal Article

In: Structure, vol. 29, no. 1, pp. 88–95.e2, 2021.

Abstract | Links | Altmetric

Gonen, Tamir; Nannenga, Brent (Ed.)

cryoEM: Methods and Protocols Book

Springer US, 2021, ISBN: 978-1-0716-0965-1.

Abstract | Links | Altmetric

2020

Martynowycz, M W; Khan, F; Hattne, J; Abramson, J; Gonen, T

MicroED structure of lipid-embedded mammalian mitochondrial voltage-dependent anion channel Journal Article

In: Proc Natl Acad Sci U S A, vol. 117, no. 51, pp. 32380–32385, 2020.

Abstract | Links | Altmetric

Zhu, Lan; Bu, Guanhong; Jing, Liang; Shi, Dan; Lee, Ming-Yue; Gonen, Tamir; Liu, Wei; Nannenga, Brent L.

Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED Journal Article

In: Structure, vol. 28, no. 10, pp. 1149–1159.e4, 2020.

Abstract | Links | Altmetric

Nannenga, Brent L.; Gonen, Tamir

Microcrystal electron diffraction methodology and applications Journal Article

In: MRS Bulletin, vol. 44, pp. 956–960, 2020.

Abstract | Links | Altmetric

Richards, Logan S.; Millán, Claudia; Miao, Jennifer; Martynowycz, Michael W.; Sawaya, Michael R.; Gonen, Tamir; Borges, Rafael J.; Usón, Isabel; Rodriguez, Jose A.

Fragment-based determination of a proteinase K structure from MicroED data using ARCIMBOLDO_SHREDDER Journal Article

In: Acta Crystallogr D Biol Crystallogr., vol. 76, no. 8, pp. 703-712, 2020.

Abstract | Links | Altmetric

Nguyen, Chi; Gonen, Tamir

Beyond protein structure determination with MicroED Journal Article

In: Curr. Opin. Struct. Biol., vol. 64, pp. 51–58, 2020.

Abstract | Links | Altmetric

Wolff, A M; Young, I D; Sierra, R G; Brewster, A S; Martynowycz, M W; Nango, E; Sugahara, M; Nakane, T; Ito, K; Aquila, A; Bhowmick, A; Biel, J T; Carbajo, S; Cohen, A E; Cortez, S; Gonzalez, A; Hino, T; Im, D; Koralek, J D; Kubo, M; Lazarou, T S; Nomura, T; Owada, S; Samelson, A J; Tanaka, T; Tanaka, R; Thompson, E M; van den Bedem, H; Woldeyes, R A; Yumoto, F; Zhao, W; Tono, K; Boutet, S; Iwata, S; Gonen, T; Sauter, N K; Fraser, J S; Thompson, M C

Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals Journal Article

In: IUCrJ, vol. 7, no. Pt 2, pp. 306–323, 2020.

Abstract | Links | Altmetric

Martynowycz, M W; Hattne, J; Gonen, T

Experimental Phasing of MicroED Data Using Radiation Damage Journal Article

In: Structure, vol. 28, no. 4, pp. 458–464, 2020.

Abstract | Links | Altmetric

2019

Dick, Markus; Sarai, Nicholas S; Martynowycz, Michael W; Gonen, Tamir; Arnold, Frances H

Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation Journal Article

In: J. Am. Chem. Soc., 2019.

Abstract | Links | Altmetric

Martynowycz, Michael W; Zhao, Wei; Hattne, Johan; Jensen, Grant J; Gonen, Tamir

Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED Journal Article

In: Structure, vol. 27, no. 10, pp. 1594–1600, 2019.

Abstract | Links | Altmetric

Hattne, Johan; Martynowycz, Michael W; Penczek, Pawel A; Gonen, Tamir

MicroED with the Falcon III direct electron detector Journal Article

In: IUCrJ, vol. 6, no. Pt 5, pp. 921–926, 2019.

Abstract | Links | Altmetric

Warmack, Rebeccah A; Boyer, David R; Zee, Chih-Te; Richards, Logan S; Sawaya, Michael R; Cascio, Duilio; Gonen, Tamir; Eisenberg, David S; Clarke, Steven G

Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface Journal Article

In: Nat Commun, vol. 10, no. 1, pp. 3357, 2019.

Abstract | Links | Altmetric

Ting, Chi P; Funk, Michael A; Halaby, Steve L; Zhang, Zhengan; Gonen, Tamir; van der Donk, Wilfred A

Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products Journal Article

In: Science, vol. 365, no. 6450, pp. 280–284, 2019.

Abstract | Links | Altmetric

Martynowycz, Michael W.; Gonen, Tamir

MicroED Structure of Hexagonal Ice Ih Online

ChemRxiv 2019.

Abstract | Links | Altmetric

de la Cruz, Jason M; Martynowycz, Michael W; Hattne, Johan; Gonen, Tamir

MicroED data collection with SerialEM Journal Article

In: Ultramicroscopy, vol. 201, pp. 77–80, 2019.

Abstract | Links | Altmetric

Nannenga, Brent L; Gonen, Tamir

The cryo-EM method microcrystal electron diffraction (MicroED) Journal Article

In: Nat. Methods, vol. 16, no. 5, pp. 369–379, 2019.

Abstract | Links | Altmetric

Martynowycz, Michael W; Zhao, Wei; Hattne, Johan; Jensen, Grant J; Gonen, Tamir

Collection of Continuous Rotation MicroED Data from Ion Beam-Milled Crystals of Any Size Journal Article

In: Structure, vol. 27, no. 3, pp. 545–548, 2019.

Abstract | Links | Altmetric

Zee, Chih-Te; Glynn, Calina; Gallagher-Jones, Marcus; Miao, Jennifer; Santiago, Carlos G; Cascio, Duilio; Gonen, Tamir; Sawaya, Michael R; Rodriguez, Jose A

Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ Journal Article

In: IUCrJ, vol. 6, no. Pt 2, pp. 197–205, 2019.

Abstract | Links | Altmetric

Ma, Jinming; Lei, Hsiang-Ting; Reyes, Francis E; Sanchez-Martinez, Silvia; Sarhan, Maen F; Hattne, Johan; Gonen, Tamir

Structural basis for substrate binding and specificity of a sodium-alanine symporter AgcS Journal Article

In: Proc. Natl. Acad. Sci. U.S.A., vol. 116, no. 6, pp. 2086–2090, 2019.

Abstract | Links | Altmetric

Griner, Sarah L; Seidler, Paul; Bowler, Jeannette; Murray, Kevin A; Yang, Tianxiao Peter; Sahay, Shruti; Sawaya, Michael R; Cascio, Duilio; Rodriguez, Jose A; Philipp, Stephan; Sosna, Justyna; Glabe, Charles G; Gonen, Tamir; Eisenberg, David S

Structure-based inhibitors of amyloid beta core suggest a common interface with tau Journal Article

In: Elife, vol. 8, 2019.

Abstract | Links | Altmetric

2018

Purdy, Michael D; Shi, Dan; Chrustowicz, Jakub; Hattne, Johan; Gonen, Tamir; Yeager, Mark

MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat Journal Article

In: Proc. Natl. Acad. Sci. U.S.A., vol. 115, no. 52, pp. 13258–13263, 2018.

Abstract | Links | Altmetric

Jones, Christopher G; Martynowycz, Michael W; Hattne, Johan; Fulton, Tyler J; Stoltz, Brian M; Rodriguez, Jose A; Nelson, Hosea M; Gonen, Tamir

The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination Journal Article

In: ACS Cent Sci, vol. 4, no. 11, pp. 1587–1592, 2018.

Abstract | Links | Altmetric

Lei, Hsiang-Ting; Ma, Jinming; Martinez, Silvia Sanchez; Gonen, Tamir

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state Journal Article

In: Nat. Struct. Mol. Biol., vol. 25, no. 6, pp. 522–527, 2018.

Abstract | Links | Altmetric

Liu, Shian; Gonen, Tamir

MicroED structure of the NaK ion channel reveals a Na⁺ partition process into the selectivity filter Journal Article

In: Commun Biol, vol. 1, pp. 38, 2018.

Abstract | Links | Altmetric

Hattne, Johan; Shi, Dan; Glynn, Calina; Zee, Chih-Te; Gallagher-Jones, Marcus; Martynowycz, Michael W; Rodriguez, Jose A; Gonen, Tamir

Analysis of Global and Site-Specific Radiation Damage in Cryo-EM Journal Article

In: Structure, vol. 26, no. 5, pp. 759–766, 2018.

Abstract | Links | Altmetric

Liu, Yuxi; Gonen, Shane; Gonen, Tamir; Yeates, Todd O

Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system Journal Article

In: Proc. Natl. Acad. Sci. U.S.A., vol. 115, no. 13, pp. 3362–3367, 2018.

Abstract | Links | Altmetric

Guenther, Elizabeth L; Ge, Peng; Trinh, Hamilton; Sawaya, Michael R; Cascio, Duilio; Boyer, David R; Gonen, Tamir; Zhou, Hong Z; Eisenberg, David S

Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2 Journal Article

In: Nat. Struct. Mol. Biol., vol. 25, no. 4, pp. 311–319, 2018.

Abstract | Links | Altmetric

Martynowycz, Michael W; Gonen, Tamir

From electron crystallography of 2D crystals to MicroED of 3D crystals Journal Article

In: Curr Opin Colloid Interface Sci, vol. 34, pp. 9–16, 2018.

Abstract | Links | Altmetric

Hughes, Michael P; Sawaya, Michael R; Boyer, David R; Goldschmidt, Lukasz; Rodriguez, Jose A; Cascio, Duilio; Chong, Lisa; Gonen, Tamir; Eisenberg, David S

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks Journal Article

In: Science, vol. 359, no. 6376, pp. 698–701, 2018.

Abstract | Links | Altmetric

Nannenga, Brent L; Gonen, Tamir

MicroED: a versatile cryoEM method for structure determination Journal Article

In: Emerg Top Life Sci, vol. 2, no. 1, pp. 1–8, 2018.

Abstract | Links | Altmetric

Gallagher-Jones, Marcus; Glynn, Calina; Boyer, David R; Martynowycz, Michael W; Hernandez, Evelyn; Miao, Jennifer; Zee, Chih-Te; Novikova, Irina V; Goldschmidt, Lukasz; McFarlane, Heather T; Helguera, Gustavo F; Evans, James E; Sawaya, Michael R; Cascio, Duilio; Eisenberg, David S; Gonen, Tamir; Rodriguez, Jose A

Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp Journal Article

In: Nat. Struct. Mol. Biol., vol. 25, no. 2, pp. 131–134, 2018.

Abstract | Links | Altmetric

2017

Seidler, P M; Boyer, D R; Rodriguez, J A; Sawaya, M R; Cascio, D; Murray, K; Gonen, T; Eisenberg, D S

Structure-based inhibitors of tau aggregation Journal Article

In: Nat Chem, vol. 10, no. 2, pp. 170–176, 2017.

Abstract | Links | Altmetric

Vergara, Sandra; Lukes, Dylan A; Martynowycz, Michael W; Santiago, Ulises; Plascencia-Villa, Germán; Weiss, Simon C; de la Cruz, Jason M; Black, David M; Alvarez, Marcos M; López-Lozano, Xochitl; Barnes, Christopher O; Lin, Guowu; Weissker, Hans-Christian; Whetten, Robert L; Gonen, Tamir; Yacaman, Miguel Jose; Calero, Guillermo

MicroED Structure of Au₁₄₆(p-MBA)₅₇ at Subatomic Resolution Reveals a Twinned FCC Cluster Journal Article

In: J Phys Chem Lett, vol. 8, no. 22, pp. 5523–5530, 2017.

Abstract | Links | Altmetric

Rodriguez, Jose A; Eisenberg, David S; Gonen, Tamir

Taking the measure of MicroED Journal Article

In: Curr. Opin. Struct. Biol., vol. 46, pp. 79–86, 2017.

Abstract | Links | Altmetric

Wright, Zoë V F; McCarthy, Stephen; Dickman, Rachel; Reyes, Francis E; Sanchez-Martinez, Silvia; Cryar, Adam; Kilford, Iian; Hall, Adrian; Takle, Andrew K; Topf, Maya; Gonen, Tamir; Thalassinos, Konstantinos; Tabor, Alethea B

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Naᵥ1.7 Journal Article

In: J. Am. Chem. Soc., vol. 139, no. 37, pp. 13063–13075, 2017.

Abstract | Links | Altmetric

131 entries « 1 of 3 »