164 entries « 1 of 4 »

2023

Danelius, Emma; Porter, Nicholas J.; Unge, Johan; Arnold, Frances H.; Gonen, Tamir

MicroED Structure of a Protoglobin Reactive Carbene Intermediate Journal Article

In: J. Am. Chem. Soc., 2023, ISSN: 1520-5126.

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Martynowycz, Michael W; Shiriaeva, Anna; Clabbers, Max T B; Nicolas, William J; Weaver, Sara J; Hattne, Johan; Gonen, Tamir

A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals Journal Article

In: Nat Commun, vol. 14, iss. 1, no. 1, pp. 1086, 2023, ISSN: 2041-1723.

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Danelius, Emma; Patel, Khushboo; Gonzalez, Brenda; Gonen, Tamir

MicroED in drug discovery Journal Article

In: Curr Opin Struct Biol, vol. 79, pp. 102549, 2023, ISSN: 1879-033X.

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2022

Clabbers, Max T. B.; Martynowycz, Michael W.; Hattne, Johan; Gonen, Tamir

Hydrogens and hydrogen-bond networks in macromolecular MicroED data Journal Article

In: J Struct Biol X, vol. 6, pp. 100078, 2022.

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Danelius, Emma; Porter, Nicholas J.; Unge, Johan; Arnold, Frances H.; Gonen, Tamir

MicroED structure of a protoglobin reactive carbene intermediate Unpublished

bioRxiv, 2022.

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Clabbers, Max T. B.; Martynowycz, Michael W.; Hattne, Johan; Nannenga, Brent L.; Gonen, Tamir

Electron-counting MicroED data with the K2 and K3 direct electron detectors Journal Article

In: J Struct Biol, 2022.

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Martynowycz, Michael W.; Shiriaeva, Anna; Clabbers, Max T. B.; Nicolas, William J.; Weaver, Sara J.; Hattne, Johan; Gonen, Tamir

A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals Online

bioRxiv 2022, visited: 26.07.2022.

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Clabbers, Max T. B.; Martynowycz, Michael W.; Hattne, Johan; Nannenga, Brent L.; Gonen, Tamir

Electron-counting MicroED data with the K2 and K3 direct electron detectors Unpublished

bioRxiv, 2022.

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Martynowycz, Michael W.; Gonen, Tamir

Unlocking the potential of microcrystal electron diffraction Journal Article

In: Physics Today, vol. 75, iss. 6, pp. 38–42, 2022.

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Nguyen, Chi; Lei, Hsiang-Ting; Lai, Louis Tung Faat; Gallenito, Marc J.; Matthies, Doreen; Gonen, Tamir

Lipid flipping in the omega-3 fatty-acid transporter Online

bioRxiv 2022, visited: 01.06.2022.

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Martynowycz, Michael W; Clabbers, Max T B; Hattne, Johan; Gonen, Tamir

Ab initio phasing macromolecular structures using electron-counted MicroED data Journal Article

In: Nat Methods, vol. 19, iss. 6, pp. 724–729, 2022, ISSN: 1548-7105.

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Porter, Nicholas J; Danelius, Emma; Gonen, Tamir; Arnold, Frances H

Biocatalytic Carbene Transfer Using Diazirines Journal Article

In: J Am Chem Soc, 2022, ISSN: 1520-5126.

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Clabbers, Max T. B.; Martynowycz, Michael W.; Hattne, Johan; Gonen, Tamir

Hydrogens and hydrogen-bond networks in macromolecular MicroED data Unpublished

bioRxiv, 2022.

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Clabbers, Max T B; Shiriaeva, Anna; Gonen, Tamir

MicroED: conception, practice and future opportunities Journal Article

In: IUCrJ, vol. 9, no. Pt 2, pp. 169–179, 2022, ISSN: 2052-2525.

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Gallenito, Marc J; Gonen, Tamir

Studying membrane proteins with MicroED Journal Article

In: Biochem Soc Trans, vol. 50, no. 1, pp. 231–239, 2022, ISSN: 1470-8752.

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2021

Martynowycz, Michael W; Clabbers, Max T B; Unge, Johan; Hattne, Johan; Gonen, Tamir

Benchmarking the ideal sample thickness in cryo-EM Journal Article

In: Proc Natl Acad Sci U S A, vol. 118, no. 49, 2021, ISSN: 1091-6490.

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Clark, Lisa J.; Bu, Guanhong; Nannenga, Brent L.; Gonen, Tamir

MicroED for the study of protein–ligand interactions and the potential for drug discovery Journal Article

In: Nat Rev Chem, vol. 5, pp. 853–858, 2021.

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Martynowycz, Michael W.; Clabbers, Max T. B.; Hattne, Johan; Gonen, Tamir

Ab initio phasing macromolecular structures using electron-counted MicroED data Unpublished

bioRxiv, 2021.

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Martynowycz, Michael W; Gonen, Tamir

Protocol for the use of focused ion-beam milling to prepare crystalline lamellae for microcrystal electron diffraction (MicroED) Journal Article

In: STAR Protoc, vol. 2, no. 3, pp. 100686, 2021, ISSN: 2666-1667.

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Martynowycz, Michael W.; Shiriaeva, Anna; Ge, Xuanrui; Hattne, Johan; Nannenga, Brent L.; Cherezov, Vadim; Gonen, Tamir

MicroED structure of the human adenosine receptor determined from a single nanocrystal in LCP Journal Article

In: Proc Natl Acad Sci U S A, vol. 118, no. 36, pp. e2106041118, 2021.

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Martynowycz, Michael W.; Clabbers, Max T. B.; Unge, Johan; Hattne, Johan; Gonen, Tamir

Benchmarking ideal sample thickness in cryo-EM using MicroED Unpublished

bioRxiv, 2021.

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Mu, Xuelang; Gillman, Cody; Nguyen, Chi; Gonen, Tamir

An Overview of Microcrystal Electron Diffraction (MicroED) Journal Article

In: Annu Rev Biochem, vol. 90, pp. 431–450, 2021, ISSN: 1545-4509.

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Lei, Hsiang-Ting; Mu, Xuelang; Hattne, Johan; Gonen, Tamir

A conformational change in the N Terminus of SLC38A9 signals mTORC1 activation Journal Article

In: Structure, vol. 29, no. 5, pp. 426–432.e8, 2021.

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Danelius, E; Gonen, T

Protein and Small Molecule Structure Determination by the Cryo-EM Method MicroED Book Chapter

In: Owens, Raymond J. (Ed.): vol. 2305, pp. 323–342, 2021.

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Martynowycz, M W; Gonen, T

Studying Membrane Protein Structures by MicroED Book Chapter

In: Schmidt-Krey, Ingeborg; Gumbart, James C. (Ed.): vol. 2302, pp. 137–151, 2021.

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Martynowycz, M W; Gonen, T

Microcrystal Electron Diffraction of Small Molecules Journal Article

In: J Vis Exp, no. 169, 2021.

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Danelius, E; Halaby, S; van der Donk, W A; Gonen, T

MicroED in natural product and small molecule research Journal Article

In: Nat Prod Rep, vol. 38, no. 3, 2021.

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Halaby, Steve; Martynowycz, Michael W.; Zhu, Ziyue; Tretiak, Sergei; Zhugayevych, Andriy; Gonen, Tamir; and Martin Seifrid,

Microcrystal Electron Diffraction for Molecular Design of Functional Non-Fullerene Acceptor Structures Journal Article

In: Chem. Mater., vol. 33, no. 3, pp. 966–977, 2021.

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Martynowycz, Michael W.; Gonen, Tamir

Ligand Incorporation into Protein Microcrystals for MicroED by On-Grid Soaking Journal Article

In: Structure, vol. 29, no. 1, pp. 88–95.e2, 2021.

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Gonen, Tamir; Nannenga, Brent (Ed.)

cryoEM: Methods and Protocols Book

Springer US, 2021, ISBN: 978-1-0716-0965-1.

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2020

Martynowycz, M W; Khan, F; Hattne, J; Abramson, J; Gonen, T

MicroED structure of lipid-embedded mammalian mitochondrial voltage-dependent anion channel Journal Article

In: Proc Natl Acad Sci U S A, vol. 117, no. 51, pp. 32380–32385, 2020.

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Zhu, Lan; Bu, Guanhong; Jing, Liang; Shi, Dan; Lee, Ming-Yue; Gonen, Tamir; Liu, Wei; Nannenga, Brent L.

Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED Journal Article

In: Structure, vol. 28, no. 10, pp. 1149–1159.e4, 2020.

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Martynowycz, Michael W.; Shiriaeva, Anna; Ge, Xuanrui; Hattne, Johan; Nannenga, Brent L.; Cherezov, Vadim; Gonen, Tamir

MicroED structure of the human adenosine receptor determined from a single nanocrystal in LCP Unpublished

bioRxiv, 2020.

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Nannenga, Brent L.; Gonen, Tamir

Microcrystal electron diffraction methodology and applications Journal Article

In: MRS Bulletin, vol. 44, pp. 956–960, 2020.

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Martynowycz, Michael W.; Khan, Farha; Hattne, Johan; Abramson, Jeff; Gonen, Tamir

MicroED structure of lipid-embedded mammalian mitochondrial voltage dependent anion channel Unpublished

bioRxiv, 2020.

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Richards, Logan S.; Millán, Claudia; Miao, Jennifer; Martynowycz, Michael W.; Sawaya, Michael R.; Gonen, Tamir; Borges, Rafael J.; Usón, Isabel; Rodriguez, Jose A.

Fragment-based determination of a proteinase K structure from MicroED data using ARCIMBOLDO_SHREDDER Journal Article

In: Acta Crystallogr D Biol Crystallogr., vol. 76, no. 8, pp. 703-712, 2020.

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Nguyen, Chi; Gonen, Tamir

Beyond protein structure determination with MicroED Journal Article

In: Curr. Opin. Struct. Biol., vol. 64, pp. 51–58, 2020.

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Martynowycz, Michael W.; Gonen, Tamir

Efficient, high-throughput ligand incorporation into protein microcrystals by on-grid soaking Unpublished

bioRxiv, 2020.

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Wolff, A M; Young, I D; Sierra, R G; Brewster, A S; Martynowycz, M W; Nango, E; Sugahara, M; Nakane, T; Ito, K; Aquila, A; Bhowmick, A; Biel, J T; Carbajo, S; Cohen, A E; Cortez, S; Gonzalez, A; Hino, T; Im, D; Koralek, J D; Kubo, M; Lazarou, T S; Nomura, T; Owada, S; Samelson, A J; Tanaka, T; Tanaka, R; Thompson, E M; van den Bedem, H; Woldeyes, R A; Yumoto, F; Zhao, W; Tono, K; Boutet, S; Iwata, S; Gonen, T; Sauter, N K; Fraser, J S; Thompson, M C

Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals Journal Article

In: IUCrJ, vol. 7, no. Pt 2, pp. 306–323, 2020.

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Martynowycz, M W; Hattne, J; Gonen, T

Experimental Phasing of MicroED Data Using Radiation Damage Journal Article

In: Structure, vol. 28, no. 4, pp. 458–464, 2020.

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2019

Dick, Markus; Sarai, Nicholas S; Martynowycz, Michael W; Gonen, Tamir; Arnold, Frances H

Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation Journal Article

In: J. Am. Chem. Soc., 2019.

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Martynowycz, Michael W.; Hattne, Johan; Gonen, Tamir

Experimental phasing of MicroED data using radiation damage Unpublished

bioRxiv, 2019.

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Martynowycz, Michael W; Zhao, Wei; Hattne, Johan; Jensen, Grant J; Gonen, Tamir

Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED Journal Article

In: Structure, vol. 27, no. 10, pp. 1594–1600, 2019.

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Wolff, Alexander M; Young, Iris D; Sierra, Raymond G; Brewster, Aaron S; Martynowycz, Michael W; Nango, Eriko; Sugahara, Michihiro; Nakane, Takanori; Ito, Kazutaka; Aquila, Andrew; Bhowmick, Asmit; Biel, Justin T; Carbajo, Sergio; Cohen, Aina E; Cortez, Saul; Gonzalez, Ana; Hino, Tomoya; Im, Dohyun; Koralek, Jake D; Kubo, Minoru; Lazarou, Tomas S; Nomura, Takashi; Owada, Shigeki; Samelson, Avi; Tanaka, Rie; Tanaka, Tomoyuki; Thompson, Erin M; van den Bedem, Henry; Woldeyes, Rahel A; Yumoto, Fumiaki; Zhao, Wei; Tono, Kensuke; Boutet, Sébastien; Iwata, So; Gonen, Tamir; Sauter, Nicholas K; Fraser, James S; Thompson, Michael C

Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals Unpublished

bioRxiv, 2019.

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Hattne, Johan; Martynowycz, Michael W; Penczek, Pawel A; Gonen, Tamir

MicroED with the Falcon III direct electron detector Journal Article

In: IUCrJ, vol. 6, no. Pt 5, pp. 921–926, 2019.

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Zhu, Lan; Bu, Guanhong; Jing, Liang; Shi, Dan; Gonen, Tamir; Liu, Wei; Nannenga, Brent L.

Structure determination from lipidic cubic phase embedded microcrystals by MicroED Unpublished

bioRxiv, 2019.

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Warmack, Rebeccah A; Boyer, David R; Zee, Chih-Te; Richards, Logan S; Sawaya, Michael R; Cascio, Duilio; Gonen, Tamir; Eisenberg, David S; Clarke, Steven G

Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface Journal Article

In: Nat Commun, vol. 10, no. 1, pp. 3357, 2019.

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Ting, Chi P; Funk, Michael A; Halaby, Steve L; Zhang, Zhengan; Gonen, Tamir; van der Donk, Wilfred A

Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products Journal Article

In: Science, vol. 365, no. 6450, pp. 280–284, 2019.

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Martynowycz, Michael W.; Gonen, Tamir

MicroED Structure of Hexagonal Ice Ih Online

ChemRxiv 2019.

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de la Cruz, Jason M; Martynowycz, Michael W; Hattne, Johan; Gonen, Tamir

MicroED data collection with SerialEM Journal Article

In: Ultramicroscopy, vol. 201, pp. 77–80, 2019.

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164 entries « 1 of 4 »