Publications

118 entries « 1 of 3 »

2020

Zhu, Lan; Bu, Guanhong; Jing, Liang; Shi, Dan; Lee, Ming-Yue; Gonen, Tamir; Liu, Wei; Nannenga, Brent L

Structure determination from lipidic cubic phase embedded microcrystals by MicroED Journal Article Forthcoming

Structure, Forthcoming.

Nguyen, Chi; Gonen, Tamir

Beyond protein structure determination with MicroED Journal Article

Curr. Opin. Struct. Biol., 64 , pp. 51–58, 2020.

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Martynowycz, Michael W; Gonen, Tamir

Efficient, high-throughput ligand incorporation into protein microcrystals by on-grid soaking Online

bioRxiv 2020.

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Wolff, A M; Young, I D; Sierra, R G; Brewster, A S; Martynowycz, M W; Nango, E; Sugahara, M; Nakane, T; Ito, K; Aquila, A; Bhowmick, A; Biel, J T; Carbajo, S; Cohen, A E; Cortez, S; Gonzalez, A; Hino, T; Im, D; Koralek, J D; Kubo, M; Lazarou, T S; Nomura, T; Owada, S; Samelson, A J; Tanaka, T; Tanaka, R; Thompson, E M; van den Bedem, H; Woldeyes, R A; Yumoto, F; Zhao, W; Tono, K; Boutet, S; Iwata, S; Gonen, T; Sauter, N K; Fraser, J S; Thompson, M C

Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals Journal Article

IUCrJ, 7 (Pt 2), pp. 306–323, 2020.

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Martynowycz, M W; Hattne, J; Gonen, T

Experimental Phasing of MicroED Data Using Radiation Damage Journal Article

Structure, 28 (4), pp. 458–464, 2020.

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2019

Dick, Markus; Sarai, Nicholas S; Martynowycz, Michael W; Gonen, Tamir; Arnold, Frances H

Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation Journal Article

J. Am. Chem. Soc., 2019.

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Martynowycz, Michael W; Zhao, Wei; Hattne, Johan; Jensen, Grant J; Gonen, Tamir

Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED Journal Article

Structure, 27 (10), pp. 1594–1600, 2019.

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Hattne, Johan; Martynowycz, Michael W; Penczek, Pawel A; Gonen, Tamir

MicroED with the Falcon III direct electron detector Journal Article

IUCrJ, 6 (Pt 5), pp. 921–926, 2019.

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Zhu, Lan ; Bu, Guanhong ; Shi, Dan ; Gonen, Tamir ; Liu Wei, Nannenga Brent L

Structure determination from lipidic cubic phase embedded microcrystals by MicroED Online

bioRxiv 2019.

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Warmack, Rebeccah A; Boyer, David R; Zee, Chih-Te; Richards, Logan S; Sawaya, Michael R; Cascio, Duilio; Gonen, Tamir; Eisenberg, David S; Clarke, Steven G

Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface Journal Article

Nat Commun, 10 (1), pp. 3357, 2019.

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Ting, Chi P; Funk, Michael A; Halaby, Steve L; Zhang, Zhengan; Gonen, Tamir; van der Donk, Wilfred A

Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products Journal Article

Science, 365 (6450), pp. 280–284, 2019.

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Martynowycz, Michael W; Gonen, Tamir

MicroED Structure of Hexagonal Ice Ih Online

ChemRxiv 2019.

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de la Cruz, Jason M; Martynowycz, Michael W; Hattne, Johan; Gonen, Tamir

MicroED data collection with SerialEM Journal Article

Ultramicroscopy, 201 , pp. 77–80, 2019.

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Nannenga, Brent L; Gonen, Tamir

The cryo-EM method microcrystal electron diffraction (MicroED) Journal Article

Nat. Methods, 16 (5), pp. 369–379, 2019.

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Martynowycz, Michael W; Zhao, Wei; Hattne, Johan; Jensen, Grant J; Gonen, Tamir

Collection of Continuous Rotation MicroED Data from Ion Beam-Milled Crystals of Any Size Journal Article

Structure, 27 (3), pp. 545–548, 2019.

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Zee, Chih-Te; Glynn, Calina; Gallagher-Jones, Marcus; Miao, Jennifer; Santiago, Carlos G; Cascio, Duilio; Gonen, Tamir; Sawaya, Michael R; Rodriguez, Jose A

Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ Journal Article

IUCrJ, 6 (Pt 2), pp. 197–205, 2019.

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Ma, Jinming; Lei, Hsiang-Ting; Reyes, Francis E; Sanchez-Martinez, Silvia; Sarhan, Maen F; Hattne, Johan; Gonen, Tamir

Structural basis for substrate binding and specificity of a sodium-alanine symporter AgcS Journal Article

Proc. Natl. Acad. Sci. U.S.A., 116 (6), pp. 2086–2090, 2019.

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Griner, Sarah L; Seidler, Paul; Bowler, Jeannette; Murray, Kevin A; Yang, Tianxiao Peter; Sahay, Shruti; Sawaya, Michael R; Cascio, Duilio; Rodriguez, Jose A; Philipp, Stephan; Sosna, Justyna; Glabe, Charles G; Gonen, Tamir; Eisenberg, David S

Structure-based inhibitors of amyloid beta core suggest a common interface with tau Journal Article

Elife, 8 , 2019.

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2018

Purdy, Michael D; Shi, Dan; Chrustowicz, Jakub; Hattne, Johan; Gonen, Tamir; Yeager, Mark

MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat Journal Article

Proc. Natl. Acad. Sci. U.S.A., 115 (52), pp. 13258–13263, 2018.

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Jones, Christopher G; Martynowycz, Michael W; Hattne, Johan; Fulton, Tyler J; Stoltz, Brian M; Rodriguez, Jose A; Nelson, Hosea M; Gonen, Tamir

The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination Journal Article

ACS Cent Sci, 4 (11), pp. 1587–1592, 2018.

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Martynowycz, Michael W; Zhao, Wei ; Hattne, Johen ; Jensen, Grant J; Gonen, Tamir

Collection of continuous rotation MicroED Data from Ion Beam Milled Crystals of Any Size Online

bioRxiv 2018.

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Ma, Jinming ; Lei, Hsiang-Ting ; Gonen, Tamir

A conformational change in the N terminus of SLC38A9 signals mTORC1 activation Online

bioRxiv 2018.

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Lei, Hsiang-Ting; Ma, Jinming; Martinez, Silvia Sanchez; Gonen, Tamir

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state Journal Article

Nat. Struct. Mol. Biol., 25 (6), pp. 522–527, 2018.

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Liu, Shian; Gonen, Tamir

MicroED structure of the NaK ion channel reveals a Na⁺ partition process into the selectivity filter Journal Article

Commun Biol, 1 , pp. 38, 2018.

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Hattne, Johan; Shi, Dan; Glynn, Calina; Zee, Chih-Te; Gallagher-Jones, Marcus; Martynowycz, Michael W; Rodriguez, Jose A; Gonen, Tamir

Analysis of Global and Site-Specific Radiation Damage in Cryo-EM Journal Article

Structure, 26 (5), pp. 759–766, 2018.

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Ma, Jinming ; Lei, Hsiang-Ting ; Reyes, Francis E; Sanchez-Martinez, Silvia ; Sarhan, Maen ; Gonen, Tamir

Structural basis for substrate binding and specificity of a sodium/alanine symporter AgcS Online

bioRxiv 2018.

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Liu, Yuxi; Gonen, Shane; Gonen, Tamir; Yeates, Todd O

Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system Journal Article

Proc. Natl. Acad. Sci. U.S.A., 115 (13), pp. 3362–3367, 2018.

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Guenther, Elizabeth L; Ge, Peng; Trinh, Hamilton; Sawaya, Michael R; Cascio, Duilio; Boyer, David R; Gonen, Tamir; Zhou, Hong Z; Eisenberg, David S

Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2 Journal Article

Nat. Struct. Mol. Biol., 25 (4), pp. 311–319, 2018.

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Martynowycz, Michael W; Gonen, Tamir

From electron crystallography of 2D crystals to MicroED of 3D crystals Journal Article

Curr Opin Colloid Interface Sci, 34 , pp. 9–16, 2018.

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Hughes, Michael P; Sawaya, Michael R; Boyer, David R; Goldschmidt, Lukasz; Rodriguez, Jose A; Cascio, Duilio; Chong, Lisa; Gonen, Tamir; Eisenberg, David S

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks Journal Article

Science, 359 (6376), pp. 698–701, 2018.

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Nannenga, Brent L; Gonen, Tamir

MicroED: a versatile cryoEM method for structure determination Journal Article

Emerg Top Life Sci, 2 (1), pp. 1–8, 2018.

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Gallagher-Jones, Marcus; Glynn, Calina; Boyer, David R; Martynowycz, Michael W; Hernandez, Evelyn; Miao, Jennifer; Zee, Chih-Te; Novikova, Irina V; Goldschmidt, Lukasz; McFarlane, Heather T; Helguera, Gustavo F; Evans, James E; Sawaya, Michael R; Cascio, Duilio; Eisenberg, David S; Gonen, Tamir; Rodriguez, Jose A

Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp Journal Article

Nat. Struct. Mol. Biol., 25 (2), pp. 131–134, 2018.

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2017

Seidler, P M; Boyer, D R; Rodriguez, J A; Sawaya, M R; Cascio, D; Murray, K; Gonen, T; Eisenberg, D S

Structure-based inhibitors of tau aggregation Journal Article

Nat Chem, 10 (2), pp. 170–176, 2017.

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Vergara, Sandra; Lukes, Dylan A; Martynowycz, Michael W; Santiago, Ulises; Plascencia-Villa, Germán; Weiss, Simon C; de la Cruz, Jason M; Black, David M; Alvarez, Marcos M; López-Lozano, Xochitl; Barnes, Christopher O; Lin, Guowu; Weissker, Hans-Christian; Whetten, Robert L; Gonen, Tamir; Yacaman, Miguel Jose; Calero, Guillermo

MicroED Structure of Au₁₄₆(p-MBA)₅₇ at Subatomic Resolution Reveals a Twinned FCC Cluster Journal Article

J Phys Chem Lett, 8 (22), pp. 5523–5530, 2017.

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Rodriguez, Jose A; Eisenberg, David S; Gonen, Tamir

Taking the measure of MicroED Journal Article

Curr. Opin. Struct. Biol., 46 , pp. 79–86, 2017.

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Wright, Zoë V F; McCarthy, Stephen; Dickman, Rachel; Reyes, Francis E; Sanchez-Martinez, Silvia; Cryar, Adam; Kilford, Iian; Hall, Adrian; Takle, Andrew K; Topf, Maya; Gonen, Tamir; Thalassinos, Konstantinos; Tabor, Alethea B

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Naᵥ1.7 Journal Article

J. Am. Chem. Soc., 139 (37), pp. 13063–13075, 2017.

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Liu, Shian; Hattne, Johan; Reyes, Francis E; Sanchez-Martinez, Silvia; de la Cruz, Jason M; Shi, Dan; Gonen, Tamir

Atomic resolution structure determination by the cryo-EM method MicroED Journal Article

Protein Sci., 26 (1), pp. 8–15, 2017.

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Hughes, Michael P; Sawaya, Michael R; Goldschidt, Lukasz ; Rodriguez Jose A. ad Cascio, Duilio ; Gonen, Tamir ; Eisenberg, David S

Low-complexity domains adhere by reversible amyloid-like interactions between kinked β-sheets Online

bioRxiv 2017.

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de la Cruz, Jason M; Martynowycz, Michael ; Hattne, Johan ; Shi, Dan ; Gonen, Tamir

A method to minimize condenser lens-induced hysteresis effects in a JEOL JEM-3200FSC microscope to enable stable cryoEM low-dose operations Online

bioRxiv 2017.

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Martynowycz, Michael W; Glynn, Calina ; Miao, Jennifer M; de la Cruz, Jason M; Hattne, Johan ; Shi, Dan ; Cascio, Duilio ; Jose, Rodriguez; Gonen, Tamir

MicroED Structures from Micrometer Thick Protein Crystals Online

bioRxiv 2017.

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Krotee, Pascal; Griner, Sarah L; Sawaya, Michael R; Cascio, Duilio; Rodriguez, Jose A; Shi, Dan; Philipp, Stephan; Murray, Kevin; Saelices, Lorena; Lee, Ji; Seidler, Paul; Glabe, Charles G; Jiang, Lin; Gonen, Tamir; Eisenberg, David S

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors Journal Article

J. Biol. Chem., 293 (8), pp. 2888–2902, 2017.

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de la Cruz, Jason M; Hattne, Johan ; Shi, Dan ; Rodriguez, Jose A; Reyes, Francis E; Gonen, Tamir

Micro- and nanocrystal preparation for MicroED and XFEL serial crystallography by fragmentation of imperfect crystals Online

Nature Protocol Exchange 2017.

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de la Cruz, Jason M; Hattne, Johan; Shi, Dan; Seidler, Paul; Rodriguez, Jose; Reyes, Francis E; Sawaya, Michael R; Cascio, Duilio; Weiss, Simon C; Kim, Sun Kyung; Hinck, Cynthia S; Hinck, Andrew P; Calero, Guillermo; Eisenberg, David; Gonen, Tamir

Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED Journal Article

Nat. Methods, 14 (4), pp. 399–402, 2017.

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Krotee, Pascal; Rodriguez, Jose A; Sawaya, Michael R; Cascio, Duilio; Reyes, Francis E; Shi, Dan; Hattne, Johan; Nannenga, Brent L; Oskarsson, Marie E; Philipp, Stephan; Griner, Sarah; Jiang, Lin; Glabe, Charles G; Westermark, Gunilla T; Gonen, Tamir; Eisenberg, David S

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity Journal Article

Elife, 6 , 2017.

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2016

Nannenga, Brent L; Gonen, Tamir

MicroED opens a new era for biological structure determination Journal Article

Curr. Opin. Struct. Biol., 40 , pp. 128–135, 2016.

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Sawaya, Michael R; Rodriguez, Jose; Cascio, Duilio; Collazo, Michael J; Shi, Dan; Reyes, Francis E; Hattne, Johan; Gonen, Tamir; Eisenberg, David S

Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED Journal Article

Proc. Natl. Acad. Sci. U.S.A., 113 (40), pp. 11232–11236, 2016.

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Bale, Jacob B; Gonen, Shane; Liu, Yuxi; Sheffler, William; Ellis, Daniel; Thomas, Chantz; Cascio, Duilio; Yeates, Todd O; Gonen, Tamir; King, Neil P; Baker, David

Accurate design of megadalton-scale two-component icosahedral protein complexes Journal Article

Science, 353 (6297), pp. 389–394, 2016.

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Hsia, Yang; Bale, Jacob B; Gonen, Shane; Shi, Dan; Sheffler, William; Fong, Kimberly K; Nattermann, Una; Xu, Chunfu; Huang, Po‐Ssu.; Ravichandran, Rashmi; Yi, Sue; Davis, Trisha N; Gonen, Tamir; King, Neil P; Baker, David

Design of a hyperstable 60-subunit protein icosahedron Journal Article

Nature, 535 (7610), pp. 136–139, 2016.

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Hattne, Johan; Shi, Dan; de la Cruz, Jason M; Reyes, Francis E; Gonen, Tamir

Modeling truncated pixel values of faint reflections in MicroED images Journal Article

J Appl Crystallogr, 49 (Pt 3), pp. 1029–1034, 2016.

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Shi, Dan; Nannenga, Brent L; de la Cruz, Jason M; Liu, Jinyang; Sawtelle, Steven; Calero, Guillermo; Reyes, Francis E; Hattne, Johan; Gonen, Tamir

The collection of MicroED data for macromolecular crystallography Journal Article

Nat Protoc, 11 (5), pp. 895–904, 2016.

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118 entries « 1 of 3 »