Research
Amino Acid Sensing and Transport
This study offers a first glimpse into a prototypical model for SLC38 transporter.
Lipid Flipping
Mfsd2a is the transporter for docosahexaenoic acid (DHA), an omega-3 fatty acid, across the blood brain barrier (BBB).
Water Permeation
Learn about the molecular mechanisms and structures that regulate water transport in biological systems, advancing our understanding of cellular processes.
Membrane Protein Complexes
Current efforts in the laboratory are to understand how Ca²⁺/CaM binds to and modulates the activity of other channels such as ion channels.
Membrane Transporters and Cellular Homeostasis
Membrane transporters involved in nutrient uptake including sugar, nitrogen, and amino acid uptake
Fragment‐Based Phase Extension
In electron crystallography membrane protein structure is determined from two-dimensional crystals where the protein is embedded in a membrane.
MicroED
Three‐dimensional electron crystallography of protein microcrystals
Self‐Assembling Proteins
Learn about computational design of genetically encoded self‐assembling proteins
Electrophysiology
We use electrophysiology and patch clamping techniques to study the function of channels and transporters.
Vibrio cholera toxin secretion channel
In collaboration with Wim Hol (UW) we studied the structure of the vibrio cholera toxin secretion channel.
Yeast Kinetochore
In collaboration with Sue Biggins (FHCRC) we studied the structure of the yeast kinetochore by electron tomography.