Overall topology and lysolipid transport by drMfsd2a

Lipid Flipping

Mfsd2a is the transporter for docosahexaenoic acid (DHA), an omega-3 fatty acid, across the blood brain barrier (BBB).

Figure 1

Water Permeation

Learn about the molecular mechanisms and structures that regulate water transport in biological systems, advancing our understanding of cellular processes.

Figure 5

Membrane Protein Complexes

Current efforts in the laboratory are to understand how Ca²⁺/CaM binds to and modulates the activity of other channels such as ion channels.

Figure 9

Fragment‐Based Phase Extension

In electron crystallography membrane protein structure is determined from two-dimensional crystals where the protein is embedded in a membrane.

Example of MicroED data: lysozyme

MicroED

Three‐dimensional electron crystallography of protein microcrystals

 The schematics of an electrophysiological measurement by patch-clamp

Electrophysiology

We use electrophysiology and patch clamping techniques to study the function of channels and transporters.

Figure 13

Yeast Kinetochore

In collaboration with Sue Biggins (FHCRC) we studied the structure of the yeast kinetochore by electron tomography.