CV for Tamir Gonen, Ph.D., MRSNZ

Investigator, Howard Hughes Medical Institute at UCLA

2005–2011Assistant Professor of Biochemistry, University of Washington, Seattle
2009–2011Howard Hughes Medical Institute Early Career Scientist
2011Associate Professor of Biochemistry (Tenured), University of Washington
2011–presentAffiliate Professor of Biochemistry, University of Washington, Seattle, WA
2011–2017Group Leader, HHMI, Janelia Research Campus, Ashburn VA
2017–PresentInvestigator, Howard Hughes Medical Institute.
2017–presentProfessor of Biological Chemistry and Physiology, David Geffen Medical School. UCLA, CA.

Honors

1996Deans List – Organic Chemistry, University of Auckland, New Zealand
1996Deans List – Inorganic Chemistry, University of Auckland, New Zealand
1997Center for Gene Technology Research Scholarship, University of Auckland, New Zealand
1997Deans List – Inorganic Chemistry, University of Auckland, New Zealand
1998Senior Prize in Biological Sciences, University of Auckland, New Zealand
1998First Class Honors in Biological Sciences, University of Auckland, New Zealand
1999University of Auckland Doctoral Scholarship, University of Auckland, New Zealand
2000Contestable Travel Fund Award, University of Auckland, New Zealand
2001Contestable Travel Fund Award, University of Auckland, New Zealand
2009American Diabetes Association Career Development Award
2009Howard Hughes Medical Institute Early Career Scientist
2010New Investigator Science in Medicine Lecture
2012Member, The Royal Society of New Zealand
2017Investigator, Howard Hughes Medical Institute
2018Chair elect, Biophysical Society cryoEM subgroup

Publications in Pubmed

Publications

130 entries « 1 of 3 »

2021

Lei, Hsiang-Ting ; Mu, Xuelang ; Hattne, Johan ; Gonen, Tamir

A Conformational Change in the N Terminus of SLC38A9 Signals mTORC1 Activation Journal Article

Structure, 29 (5), pp. 426–432.e8, 2021.

Abstract | Links | Altmetric

Danelius, E; Gonen, T

Protein and Small Molecule Structure Determination by the Cryo-EM Method MicroED Book Chapter

Owens, Raymond J (Ed.): 2305 , pp. 323–342, 2021.

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Martynowycz, M W; Gonen, T

Studying Membrane Protein Structures by MicroED Book Chapter

Schmidt-Krey, Ingeborg; Gumbart, James C (Ed.): 2302 , pp. 137–151, 2021.

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Martynowycz, M W; Gonen, T

Microcrystal Electron Diffraction of Small Molecules Journal Article

J Vis Exp, (169), 2021.

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Halaby, Steve; Martynowycz, Michael W; Zhu, Ziyue; Tretiak, Sergei; Zhugayevych, Andriy; Gonen, Tamir; and Seifrid, Martin

Microcrystal Electron Diffraction for Molecular Design of Functional Non-Fullerene Acceptor Structures Journal Article

Chem. Mater., 33 (3), pp. 966–977, 2021.

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Martynowycz, Michael W; Gonen, Tamir

Ligand Incorporation into Protein Microcrystals for MicroED by On-Grid Soaking Journal Article

Structure, 29 (1), pp. 88–95.e2, 2021.

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Gonen, Tamir; Nannenga, Brent (Ed.)

cryoEM: Methods and Protocols Book

Springer US, 2021, ISBN: 978-1-0716-0965-1.

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2020

Martynowycz, M W; Khan, F; Hattne, J; Abramson, J; Gonen, T

MicroED structure of lipid-embedded mammalian mitochondrial voltage-dependent anion channel Journal Article

Proc Natl Acad Sci U S A, 117 (51), pp. 32380–32385, 2020.

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Zhu, Lan; Bu, Guanhong; Jing, Liang; Shi, Dan; Lee, Ming-Yue; Gonen, Tamir; Liu, Wei; Nannenga, Brent L

Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED Journal Article

Structure, 28 (10), pp. 1149–1159.e4, 2020.

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Martynowycz, Michael W; Shiriaeva, Anna ; Ge, Xuanrui ; Hattne, Johan ; Nannenga, Brent L; Cherezov, Vadim ; Gonen, Tamir

MicroED structure of the human adenosine receptor determined from a single nanocrystal in LCP Online

bioRxiv 2020.

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Danelius, E; Halaby, S; van der Donk, W A; Gonen, T

MicroED in natural product and small molecule research Journal Article

Nat Prod Rep, 2020.

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Richards, Logan S; Millán, Claudia; Miao, Jennifer; Martynowycz, Michael W; Sawaya, Michael R; Gonen, Tamir; Borges, Rafael J; Usón, Isabel; Rodriguez, Jose A

Fragment-based determination of a proteinase K structure from MicroED data using ARCIMBOLDO_SHREDDER Journal Article

Acta Crystallogr D Biol Crystallogr., 76 (8), pp. 703-712, 2020.

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Nguyen, Chi; Gonen, Tamir

Beyond protein structure determination with MicroED Journal Article

Curr. Opin. Struct. Biol., 64 , pp. 51–58, 2020.

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Martynowycz, Michael W; Gonen, Tamir

Efficient, high-throughput ligand incorporation into protein microcrystals by on-grid soaking Online

bioRxiv 2020.

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Wolff, A M; Young, I D; Sierra, R G; Brewster, A S; Martynowycz, M W; Nango, E; Sugahara, M; Nakane, T; Ito, K; Aquila, A; Bhowmick, A; Biel, J T; Carbajo, S; Cohen, A E; Cortez, S; Gonzalez, A; Hino, T; Im, D; Koralek, J D; Kubo, M; Lazarou, T S; Nomura, T; Owada, S; Samelson, A J; Tanaka, T; Tanaka, R; Thompson, E M; van den Bedem, H; Woldeyes, R A; Yumoto, F; Zhao, W; Tono, K; Boutet, S; Iwata, S; Gonen, T; Sauter, N K; Fraser, J S; Thompson, M C

Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals Journal Article

IUCrJ, 7 (Pt 2), pp. 306–323, 2020.

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Martynowycz, M W; Hattne, J; Gonen, T

Experimental Phasing of MicroED Data Using Radiation Damage Journal Article

Structure, 28 (4), pp. 458–464, 2020.

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2019

Dick, Markus; Sarai, Nicholas S; Martynowycz, Michael W; Gonen, Tamir; Arnold, Frances H

Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation Journal Article

J. Am. Chem. Soc., 2019.

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Martynowycz, Michael W; Zhao, Wei; Hattne, Johan; Jensen, Grant J; Gonen, Tamir

Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED Journal Article

Structure, 27 (10), pp. 1594–1600, 2019.

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Hattne, Johan; Martynowycz, Michael W; Penczek, Pawel A; Gonen, Tamir

MicroED with the Falcon III direct electron detector Journal Article

IUCrJ, 6 (Pt 5), pp. 921–926, 2019.

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Zhu, Lan ; Bu, Guanhong ; Shi, Dan ; Gonen, Tamir ; Liu Wei, Nannenga Brent L

Structure determination from lipidic cubic phase embedded microcrystals by MicroED Online

bioRxiv 2019.

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Warmack, Rebeccah A; Boyer, David R; Zee, Chih-Te; Richards, Logan S; Sawaya, Michael R; Cascio, Duilio; Gonen, Tamir; Eisenberg, David S; Clarke, Steven G

Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface Journal Article

Nat Commun, 10 (1), pp. 3357, 2019.

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Ting, Chi P; Funk, Michael A; Halaby, Steve L; Zhang, Zhengan; Gonen, Tamir; van der Donk, Wilfred A

Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products Journal Article

Science, 365 (6450), pp. 280–284, 2019.

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Martynowycz, Michael W; Gonen, Tamir

MicroED Structure of Hexagonal Ice Ih Online

ChemRxiv 2019.

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de la Cruz, Jason M; Martynowycz, Michael W; Hattne, Johan; Gonen, Tamir

MicroED data collection with SerialEM Journal Article

Ultramicroscopy, 201 , pp. 77–80, 2019.

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Nannenga, Brent L; Gonen, Tamir

The cryo-EM method microcrystal electron diffraction (MicroED) Journal Article

Nat. Methods, 16 (5), pp. 369–379, 2019.

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Martynowycz, Michael W; Zhao, Wei; Hattne, Johan; Jensen, Grant J; Gonen, Tamir

Collection of Continuous Rotation MicroED Data from Ion Beam-Milled Crystals of Any Size Journal Article

Structure, 27 (3), pp. 545–548, 2019.

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Zee, Chih-Te; Glynn, Calina; Gallagher-Jones, Marcus; Miao, Jennifer; Santiago, Carlos G; Cascio, Duilio; Gonen, Tamir; Sawaya, Michael R; Rodriguez, Jose A

Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ Journal Article

IUCrJ, 6 (Pt 2), pp. 197–205, 2019.

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Ma, Jinming; Lei, Hsiang-Ting; Reyes, Francis E; Sanchez-Martinez, Silvia; Sarhan, Maen F; Hattne, Johan; Gonen, Tamir

Structural basis for substrate binding and specificity of a sodium-alanine symporter AgcS Journal Article

Proc. Natl. Acad. Sci. U.S.A., 116 (6), pp. 2086–2090, 2019.

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Griner, Sarah L; Seidler, Paul; Bowler, Jeannette; Murray, Kevin A; Yang, Tianxiao Peter; Sahay, Shruti; Sawaya, Michael R; Cascio, Duilio; Rodriguez, Jose A; Philipp, Stephan; Sosna, Justyna; Glabe, Charles G; Gonen, Tamir; Eisenberg, David S

Structure-based inhibitors of amyloid beta core suggest a common interface with tau Journal Article

Elife, 8 , 2019.

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2018

Purdy, Michael D; Shi, Dan; Chrustowicz, Jakub; Hattne, Johan; Gonen, Tamir; Yeager, Mark

MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat Journal Article

Proc. Natl. Acad. Sci. U.S.A., 115 (52), pp. 13258–13263, 2018.

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Jones, Christopher G; Martynowycz, Michael W; Hattne, Johan; Fulton, Tyler J; Stoltz, Brian M; Rodriguez, Jose A; Nelson, Hosea M; Gonen, Tamir

The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination Journal Article

ACS Cent Sci, 4 (11), pp. 1587–1592, 2018.

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Martynowycz, Michael W; Zhao, Wei ; Hattne, Johen ; Jensen, Grant J; Gonen, Tamir

Collection of continuous rotation MicroED Data from Ion Beam Milled Crystals of Any Size Online

bioRxiv 2018.

Abstract | Links | Altmetric

Ma, Jinming ; Lei, Hsiang-Ting ; Gonen, Tamir

A conformational change in the N terminus of SLC38A9 signals mTORC1 activation Online

bioRxiv 2018.

Abstract | Links | Altmetric

Lei, Hsiang-Ting; Ma, Jinming; Martinez, Silvia Sanchez; Gonen, Tamir

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state Journal Article

Nat. Struct. Mol. Biol., 25 (6), pp. 522–527, 2018.

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Liu, Shian; Gonen, Tamir

MicroED structure of the NaK ion channel reveals a Na⁺ partition process into the selectivity filter Journal Article

Commun Biol, 1 , pp. 38, 2018.

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Hattne, Johan; Shi, Dan; Glynn, Calina; Zee, Chih-Te; Gallagher-Jones, Marcus; Martynowycz, Michael W; Rodriguez, Jose A; Gonen, Tamir

Analysis of Global and Site-Specific Radiation Damage in Cryo-EM Journal Article

Structure, 26 (5), pp. 759–766, 2018.

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Ma, Jinming ; Lei, Hsiang-Ting ; Reyes, Francis E; Sanchez-Martinez, Silvia ; Sarhan, Maen ; Gonen, Tamir

Structural basis for substrate binding and specificity of a sodium/alanine symporter AgcS Online

bioRxiv 2018.

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Liu, Yuxi; Gonen, Shane; Gonen, Tamir; Yeates, Todd O

Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system Journal Article

Proc. Natl. Acad. Sci. U.S.A., 115 (13), pp. 3362–3367, 2018.

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Guenther, Elizabeth L; Ge, Peng; Trinh, Hamilton; Sawaya, Michael R; Cascio, Duilio; Boyer, David R; Gonen, Tamir; Zhou, Hong Z; Eisenberg, David S

Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2 Journal Article

Nat. Struct. Mol. Biol., 25 (4), pp. 311–319, 2018.

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Martynowycz, Michael W; Gonen, Tamir

From electron crystallography of 2D crystals to MicroED of 3D crystals Journal Article

Curr Opin Colloid Interface Sci, 34 , pp. 9–16, 2018.

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Hughes, Michael P; Sawaya, Michael R; Boyer, David R; Goldschmidt, Lukasz; Rodriguez, Jose A; Cascio, Duilio; Chong, Lisa; Gonen, Tamir; Eisenberg, David S

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks Journal Article

Science, 359 (6376), pp. 698–701, 2018.

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Nannenga, Brent L; Gonen, Tamir

MicroED: a versatile cryoEM method for structure determination Journal Article

Emerg Top Life Sci, 2 (1), pp. 1–8, 2018.

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Gallagher-Jones, Marcus; Glynn, Calina; Boyer, David R; Martynowycz, Michael W; Hernandez, Evelyn; Miao, Jennifer; Zee, Chih-Te; Novikova, Irina V; Goldschmidt, Lukasz; McFarlane, Heather T; Helguera, Gustavo F; Evans, James E; Sawaya, Michael R; Cascio, Duilio; Eisenberg, David S; Gonen, Tamir; Rodriguez, Jose A

Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp Journal Article

Nat. Struct. Mol. Biol., 25 (2), pp. 131–134, 2018.

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2017

Seidler, P M; Boyer, D R; Rodriguez, J A; Sawaya, M R; Cascio, D; Murray, K; Gonen, T; Eisenberg, D S

Structure-based inhibitors of tau aggregation Journal Article

Nat Chem, 10 (2), pp. 170–176, 2017.

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Vergara, Sandra; Lukes, Dylan A; Martynowycz, Michael W; Santiago, Ulises; Plascencia-Villa, Germán; Weiss, Simon C; de la Cruz, Jason M; Black, David M; Alvarez, Marcos M; López-Lozano, Xochitl; Barnes, Christopher O; Lin, Guowu; Weissker, Hans-Christian; Whetten, Robert L; Gonen, Tamir; Yacaman, Miguel Jose; Calero, Guillermo

MicroED Structure of Au₁₄₆(p-MBA)₅₇ at Subatomic Resolution Reveals a Twinned FCC Cluster Journal Article

J Phys Chem Lett, 8 (22), pp. 5523–5530, 2017.

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Rodriguez, Jose A; Eisenberg, David S; Gonen, Tamir

Taking the measure of MicroED Journal Article

Curr. Opin. Struct. Biol., 46 , pp. 79–86, 2017.

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Wright, Zoë V F; McCarthy, Stephen; Dickman, Rachel; Reyes, Francis E; Sanchez-Martinez, Silvia; Cryar, Adam; Kilford, Iian; Hall, Adrian; Takle, Andrew K; Topf, Maya; Gonen, Tamir; Thalassinos, Konstantinos; Tabor, Alethea B

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Naᵥ1.7 Journal Article

J. Am. Chem. Soc., 139 (37), pp. 13063–13075, 2017.

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Liu, Shian; Hattne, Johan; Reyes, Francis E; Sanchez-Martinez, Silvia; de la Cruz, Jason M; Shi, Dan; Gonen, Tamir

Atomic resolution structure determination by the cryo-EM method MicroED Journal Article

Protein Sci., 26 (1), pp. 8–15, 2017.

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Hughes, Michael P; Sawaya, Michael R; Goldschidt, Lukasz ; Rodriguez Jose A. ad Cascio, Duilio ; Gonen, Tamir ; Eisenberg, David S

Low-complexity domains adhere by reversible amyloid-like interactions between kinked β-sheets Online

bioRxiv 2017.

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de la Cruz, Jason M; Martynowycz, Michael ; Hattne, Johan ; Shi, Dan ; Gonen, Tamir

A method to minimize condenser lens-induced hysteresis effects in a JEOL JEM-3200FSC microscope to enable stable cryoEM low-dose operations Online

bioRxiv 2017.

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130 entries « 1 of 3 »