192 entries « 2 of 4 »

2021

Danelius, E; Gonen, T

Protein and Small Molecule Structure Determination by the Cryo-EM Method MicroED

In: Owens, Raymond J. (Ed.): vol. 2305, pp. 323–342, 2021.

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Martynowycz, M W; Gonen, T

Studying Membrane Protein Structures by MicroED

In: Schmidt-Krey, Ingeborg; Gumbart, James C. (Ed.): vol. 2302, pp. 137–151, 2021.

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Martynowycz, M W; Gonen, T

Microcrystal Electron Diffraction of Small Molecules

In: J Vis Exp, no. 169, 2021.

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Halaby, Steve; Martynowycz, Michael W.; Zhu, Ziyue; Tretiak, Sergei; Zhugayevych, Andriy; Gonen, Tamir; and Martin Seifrid,

Microcrystal Electron Diffraction for Molecular Design of Functional Non-Fullerene Acceptor Structures

In: Chem. Mater., vol. 33, no. 3, pp. 966–977, 2021.

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Martynowycz, Michael W.; Gonen, Tamir

Ligand Incorporation into Protein Microcrystals for MicroED by On-Grid Soaking

In: Structure, vol. 29, no. 1, pp. 88–95.e2, 2021.

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2020

Martynowycz, M W; Khan, F; Hattne, J; Abramson, J; Gonen, T

MicroED structure of lipid-embedded mammalian mitochondrial voltage-dependent anion channel

In: Proc Natl Acad Sci U S A, vol. 117, no. 51, pp. 32380–32385, 2020.

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Zhu, Lan; Bu, Guanhong; Jing, Liang; Shi, Dan; Lee, Ming-Yue; Gonen, Tamir; Liu, Wei; Nannenga, Brent L.

Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED

In: Structure, vol. 28, no. 10, pp. 1149–1159.e4, 2020.

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Martynowycz, Michael W.; Shiriaeva, Anna; Ge, Xuanrui; Hattne, Johan; Nannenga, Brent L.; Cherezov, Vadim; Gonen, Tamir

MicroED structure of the human adenosine receptor determined from a single nanocrystal in LCP

bioRxiv, 2020.

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Nannenga, Brent L.; Gonen, Tamir

Microcrystal electron diffraction methodology and applications

In: MRS Bulletin, vol. 44, pp. 956–960, 2020.

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Martynowycz, Michael W.; Khan, Farha; Hattne, Johan; Abramson, Jeff; Gonen, Tamir

MicroED structure of lipid-embedded mammalian mitochondrial voltage dependent anion channel

bioRxiv, 2020.

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Danelius, E; Halaby, S; van der Donk, W A; Gonen, T

MicroED in natural product and small molecule research

In: Nat Prod Rep, vol. 38, no. 3, 2020.

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Richards, Logan S.; Millán, Claudia; Miao, Jennifer; Martynowycz, Michael W.; Sawaya, Michael R.; Gonen, Tamir; Borges, Rafael J.; Usón, Isabel; Rodriguez, Jose A.

Fragment-based determination of a proteinase K structure from MicroED data using ARCIMBOLDO_SHREDDER

In: Acta Crystallogr D Biol Crystallogr., vol. 76, no. 8, pp. 703-712, 2020.

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Nguyen, Chi; Gonen, Tamir

Beyond protein structure determination with MicroED

In: Curr. Opin. Struct. Biol., vol. 64, pp. 51–58, 2020.

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Martynowycz, Michael W.; Gonen, Tamir

Efficient, high-throughput ligand incorporation into protein microcrystals by on-grid soaking

bioRxiv, 2020.

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Martynowycz, M W; Hattne, J; Gonen, T

Experimental Phasing of MicroED Data Using Radiation Damage

In: Structure, vol. 28, no. 4, pp. 458–464, 2020.

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Wolff, A M; Young, I D; Sierra, R G; Brewster, A S; Martynowycz, M W; Nango, E; Sugahara, M; Nakane, T; Ito, K; Aquila, A; Bhowmick, A; Biel, J T; Carbajo, S; Cohen, A E; Cortez, S; Gonzalez, A; Hino, T; Im, D; Koralek, J D; Kubo, M; Lazarou, T S; Nomura, T; Owada, S; Samelson, A J; Tanaka, T; Tanaka, R; Thompson, E M; van den Bedem, H; Woldeyes, R A; Yumoto, F; Zhao, W; Tono, K; Boutet, S; Iwata, S; Gonen, T; Sauter, N K; Fraser, J S; Thompson, M C

Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals

In: IUCrJ, vol. 7, no. Pt 2, pp. 306–323, 2020.

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2019

Dick, Markus; Sarai, Nicholas S; Martynowycz, Michael W; Gonen, Tamir; Arnold, Frances H

Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation

In: J. Am. Chem. Soc., 2019.

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Martynowycz, Michael W.; Hattne, Johan; Gonen, Tamir

Experimental phasing of MicroED data using radiation damage

bioRxiv, 2019.

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Griner, Sarah L; Seidler, Paul; Bowler, Jeannette; Murray, Kevin A; Yang, Tianxiao Peter; Sahay, Shruti; Sawaya, Michael R; Cascio, Duilio; Rodriguez, Jose A; Philipp, Stephan; Sosna, Justyna; Glabe, Charles G; Gonen, Tamir; Eisenberg, David S

Structure-based inhibitors of amyloid beta core suggest a common interface with tau

In: Elife, vol. 8, 2019.

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Martynowycz, Michael W; Zhao, Wei; Hattne, Johan; Jensen, Grant J; Gonen, Tamir

Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED

In: Structure, vol. 27, no. 10, pp. 1594–1600, 2019.

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Wolff, Alexander M; Young, Iris D; Sierra, Raymond G; Brewster, Aaron S; Martynowycz, Michael W; Nango, Eriko; Sugahara, Michihiro; Nakane, Takanori; Ito, Kazutaka; Aquila, Andrew; Bhowmick, Asmit; Biel, Justin T; Carbajo, Sergio; Cohen, Aina E; Cortez, Saul; Gonzalez, Ana; Hino, Tomoya; Im, Dohyun; Koralek, Jake D; Kubo, Minoru; Lazarou, Tomas S; Nomura, Takashi; Owada, Shigeki; Samelson, Avi; Tanaka, Rie; Tanaka, Tomoyuki; Thompson, Erin M; van den Bedem, Henry; Woldeyes, Rahel A; Yumoto, Fumiaki; Zhao, Wei; Tono, Kensuke; Boutet, Sébastien; Iwata, So; Gonen, Tamir; Sauter, Nicholas K; Fraser, James S; Thompson, Michael C

Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals

bioRxiv, 2019.

Abstract | Links | Altmetric

Dick, Markus; Sarai, Nicholas S.; Martynowycz, Michael W.; Gonen, Tamir; Arnold, Frances H.

Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation

ChemRxiv, 2019.

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Hattne, Johan; Martynowycz, Michael W; Penczek, Pawel A; Gonen, Tamir

MicroED with the Falcon III direct electron detector

In: IUCrJ, vol. 6, no. Pt 5, pp. 921–926, 2019.

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Zhu, Lan; Bu, Guanhong; Jing, Liang; Shi, Dan; Gonen, Tamir; Liu, Wei; Nannenga, Brent L.

Structure determination from lipidic cubic phase embedded microcrystals by MicroED

bioRxiv, 2019.

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Warmack, Rebeccah A; Boyer, David R; Zee, Chih-Te; Richards, Logan S; Sawaya, Michael R; Cascio, Duilio; Gonen, Tamir; Eisenberg, David S; Clarke, Steven G

Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface

In: Nat Commun, vol. 10, no. 1, pp. 3357, 2019.

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Ting, Chi P; Funk, Michael A; Halaby, Steve L; Zhang, Zhengan; Gonen, Tamir; van der Donk, Wilfred A

Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products

In: Science, vol. 365, no. 6450, pp. 280–284, 2019.

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Martynowycz, Michael W.; Gonen, Tamir

MicroED Structure of Hexagonal Ice Ih

ChemRxiv 2019.

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de la Cruz, Jason M; Martynowycz, Michael W; Hattne, Johan; Gonen, Tamir

MicroED data collection with SerialEM

In: Ultramicroscopy, vol. 201, pp. 77–80, 2019.

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Nannenga, Brent L; Gonen, Tamir

The cryo-EM method microcrystal electron diffraction (MicroED)

In: Nat. Methods, vol. 16, no. 5, pp. 369–379, 2019.

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Hattne, Johan; Martynowycz, Michael W.; Gonen, Tamir

MicroED with the Falcon III direct electron detector

bioRxiv, 2019.

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Martynowycz, Michael W.; Zhao, Wei; Hattne, Johan; Jensen, Grant J.; Gonen, Tamir

Qualitative analyses of polishing and pre-coating FIB milled crystals for MicroED

bioRxiv, 2019.

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Martynowycz, Michael W; Zhao, Wei; Hattne, Johan; Jensen, Grant J; Gonen, Tamir

Collection of Continuous Rotation MicroED Data from Ion Beam-Milled Crystals of Any Size

In: Structure, vol. 27, no. 3, pp. 545–548, 2019.

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Zee, Chih-Te; Glynn, Calina; Gallagher-Jones, Marcus; Miao, Jennifer; Santiago, Carlos G; Cascio, Duilio; Gonen, Tamir; Sawaya, Michael R; Rodriguez, Jose A

Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ

In: IUCrJ, vol. 6, no. Pt 2, pp. 197–205, 2019.

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Ma, Jinming; Lei, Hsiang-Ting; Reyes, Francis E; Sanchez-Martinez, Silvia; Sarhan, Maen F; Hattne, Johan; Gonen, Tamir

Structural basis for substrate binding and specificity of a sodium-alanine symporter AgcS

In: Proc. Natl. Acad. Sci. U.S.A., vol. 116, no. 6, pp. 2086–2090, 2019.

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2018

Purdy, Michael D; Shi, Dan; Chrustowicz, Jakub; Hattne, Johan; Gonen, Tamir; Yeager, Mark

MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat

In: Proc. Natl. Acad. Sci. U.S.A., vol. 115, no. 52, pp. 13258–13263, 2018.

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Zee, Chih-Te; Glynn, Calina; Gallagher-Jones, Marcus; Miao, Jennifer; Santiago, Carlos G.; Cascio, Duilio; Gonen, Tamir; Sawaya, Michael R.; Rodriguez, Jose A.

Homochiral and racemic MicroED structures of a peptide from the ice nucleation protein InaZ

bioRxiv, 2018.

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Jones, Christopher G; Martynowycz, Michael W; Hattne, Johan; Fulton, Tyler J; Stoltz, Brian M; Rodriguez, Jose A; Nelson, Hosea M; Gonen, Tamir

The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination

In: ACS Cent Sci, vol. 4, no. 11, pp. 1587–1592, 2018.

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de la Cruz, M. Jason; Martynowycz, Michael W.; Hattne, Johan; Gonen, Tamir

MicroED data collection with SerialEM

bioRxiv, 2018.

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Jones, Christopher G.; Martynowycz, Michael W.; Hattne, Johan; Fulton, Tyler J.; Stoltz, Brian M.; Rodriguez, Jose A.; Nelson, Hosea; Gonen, Tamir

The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination

ChemRxiv, 2018.

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Martynowycz, Michael W.; Zhao, Wei; Hattne, Johan; Jensen, Grant J.; Gonen, Tamir

Collection of continuous rotation MicroED Data from Ion Beam Milled Crystals of Any Size

bioRxiv, 2018.

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Jinming, Ma; Lei, Hsiang-Ting; Gonen, Tamir

A conformational change in the N terminus of SLC38A9 signals mTORC1 activation

bioRxiv, 2018.

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Lei, Hsiang-Ting; Ma, Jinming; Martinez, Silvia Sanchez; Gonen, Tamir

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state

In: Nat. Struct. Mol. Biol., vol. 25, no. 6, pp. 522–527, 2018.

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Liu, Shian; Gonen, Tamir

MicroED structure of the NaK ion channel reveals a Na⁺ partition process into the selectivity filter

In: Commun Biol, vol. 1, pp. 38, 2018.

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Hattne, Johan; Shi, Dan; Glynn, Calina; Zee, Chih-Te; Gallagher-Jones, Marcus; Martynowycz, Michael W; Rodriguez, Jose A; Gonen, Tamir

Analysis of Global and Site-Specific Radiation Damage in Cryo-EM

In: Structure, vol. 26, no. 5, pp. 759–766, 2018.

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Ma, Jinming; Lei, Hsiang-Ting; Reyes, Francis E.; Sanchez-Martinez, Silvia; Sarhan, Maen; Gonen, Tamir

Structural basis for substrate binding and specificity of a sodium/alanine symporter AgcS

bioRxiv, 2018.

Abstract | Links | Altmetric

Lei, Hsiang-Ting; Ma, Jinming; Martinez, Silvia Sanchez; Gonen, Tamir

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state

bioRxiv, 2018.

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Guenther, Elizabeth L; Ge, Peng; Trinh, Hamilton; Sawaya, Michael R; Cascio, Duilio; Boyer, David R; Gonen, Tamir; Zhou, Hong Z; Eisenberg, David S

Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2

In: Nat. Struct. Mol. Biol., vol. 25, no. 4, pp. 311–319, 2018.

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Liu, Yuxi; Gonen, Shane; Gonen, Tamir; Yeates, Todd O

Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system

In: Proc. Natl. Acad. Sci. U.S.A., vol. 115, no. 13, pp. 3362–3367, 2018.

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Martynowycz, Michael W; Gonen, Tamir

From electron crystallography of 2D crystals to MicroED of 3D crystals

In: Curr Opin Colloid Interface Sci, vol. 34, pp. 9–16, 2018.

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Krotee, Pascal; Griner, Sarah L; Sawaya, Michael R; Cascio, Duilio; Rodriguez, Jose A; Shi, Dan; Philipp, Stephan; Murray, Kevin; Saelices, Lorena; Lee, Ji; Seidler, Paul; Glabe, Charles G; Jiang, Lin; Gonen, Tamir; Eisenberg, David S

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors

In: J. Biol. Chem., vol. 293, no. 8, pp. 2888–2902, 2018.

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192 entries « 2 of 4 »