170 entries « 2 of 4 »

2019

Hattne, Johan; Martynowycz, Michael W; Penczek, Pawel A; Gonen, Tamir

MicroED with the Falcon III direct electron detector

In: IUCrJ, vol. 6, no. Pt 5, pp. 921–926, 2019.

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Zhu, Lan; Bu, Guanhong; Jing, Liang; Shi, Dan; Gonen, Tamir; Liu, Wei; Nannenga, Brent L.

Structure determination from lipidic cubic phase embedded microcrystals by MicroED

bioRxiv, 2019.

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Warmack, Rebeccah A; Boyer, David R; Zee, Chih-Te; Richards, Logan S; Sawaya, Michael R; Cascio, Duilio; Gonen, Tamir; Eisenberg, David S; Clarke, Steven G

Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface

In: Nat Commun, vol. 10, no. 1, pp. 3357, 2019.

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Ting, Chi P; Funk, Michael A; Halaby, Steve L; Zhang, Zhengan; Gonen, Tamir; van der Donk, Wilfred A

Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products

In: Science, vol. 365, no. 6450, pp. 280–284, 2019.

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Martynowycz, Michael W.; Gonen, Tamir

MicroED Structure of Hexagonal Ice Ih

ChemRxiv 2019.

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de la Cruz, Jason M; Martynowycz, Michael W; Hattne, Johan; Gonen, Tamir

MicroED data collection with SerialEM

In: Ultramicroscopy, vol. 201, pp. 77–80, 2019.

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Nannenga, Brent L; Gonen, Tamir

The cryo-EM method microcrystal electron diffraction (MicroED)

In: Nat. Methods, vol. 16, no. 5, pp. 369–379, 2019.

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Hattne, Johan; Martynowycz, Michael W.; Gonen, Tamir

MicroED with the Falcon III direct electron detector

bioRxiv, 2019.

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Martynowycz, Michael W.; Zhao, Wei; Hattne, Johan; Jensen, Grant J.; Gonen, Tamir

Qualitative analyses of polishing and pre-coating FIB milled crystals for MicroED

bioRxiv, 2019.

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Martynowycz, Michael W; Zhao, Wei; Hattne, Johan; Jensen, Grant J; Gonen, Tamir

Collection of Continuous Rotation MicroED Data from Ion Beam-Milled Crystals of Any Size

In: Structure, vol. 27, no. 3, pp. 545–548, 2019.

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Zee, Chih-Te; Glynn, Calina; Gallagher-Jones, Marcus; Miao, Jennifer; Santiago, Carlos G; Cascio, Duilio; Gonen, Tamir; Sawaya, Michael R; Rodriguez, Jose A

Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ

In: IUCrJ, vol. 6, no. Pt 2, pp. 197–205, 2019.

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Ma, Jinming; Lei, Hsiang-Ting; Reyes, Francis E; Sanchez-Martinez, Silvia; Sarhan, Maen F; Hattne, Johan; Gonen, Tamir

Structural basis for substrate binding and specificity of a sodium-alanine symporter AgcS

In: Proc. Natl. Acad. Sci. U.S.A., vol. 116, no. 6, pp. 2086–2090, 2019.

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Griner, Sarah L; Seidler, Paul; Bowler, Jeannette; Murray, Kevin A; Yang, Tianxiao Peter; Sahay, Shruti; Sawaya, Michael R; Cascio, Duilio; Rodriguez, Jose A; Philipp, Stephan; Sosna, Justyna; Glabe, Charles G; Gonen, Tamir; Eisenberg, David S

Structure-based inhibitors of amyloid beta core suggest a common interface with tau

In: Elife, vol. 8, 2019.

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2018

Purdy, Michael D; Shi, Dan; Chrustowicz, Jakub; Hattne, Johan; Gonen, Tamir; Yeager, Mark

MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat

In: Proc. Natl. Acad. Sci. U.S.A., vol. 115, no. 52, pp. 13258–13263, 2018.

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Zee, Chih-Te; Glynn, Calina; Gallagher-Jones, Marcus; Miao, Jennifer; Santiago, Carlos G.; Cascio, Duilio; Gonen, Tamir; Sawaya, Michael R.; Rodriguez, Jose A.

Homochiral and racemic MicroED structures of a peptide from the ice nucleation protein InaZ

bioRxiv, 2018.

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Jones, Christopher G; Martynowycz, Michael W; Hattne, Johan; Fulton, Tyler J; Stoltz, Brian M; Rodriguez, Jose A; Nelson, Hosea M; Gonen, Tamir

The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination

In: ACS Cent Sci, vol. 4, no. 11, pp. 1587–1592, 2018.

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de la Cruz, M. Jason; Martynowycz, Michael W.; Hattne, Johan; Gonen, Tamir

MicroED data collection with SerialEM

bioRxiv, 2018.

Abstract | Links | Altmetric

Martynowycz, Michael W.; Zhao, Wei; Hattne, Johan; Jensen, Grant J.; Gonen, Tamir

Collection of continuous rotation MicroED Data from Ion Beam Milled Crystals of Any Size

bioRxiv, 2018.

Abstract | Links | Altmetric

Jinming, Ma; Lei, Hsiang-Ting; Gonen, Tamir

A conformational change in the N terminus of SLC38A9 signals mTORC1 activation

bioRxiv, 2018.

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Lei, Hsiang-Ting; Ma, Jinming; Martinez, Silvia Sanchez; Gonen, Tamir

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state

In: Nat. Struct. Mol. Biol., vol. 25, no. 6, pp. 522–527, 2018.

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Liu, Shian; Gonen, Tamir

MicroED structure of the NaK ion channel reveals a Na⁺ partition process into the selectivity filter

In: Commun Biol, vol. 1, pp. 38, 2018.

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Hattne, Johan; Shi, Dan; Glynn, Calina; Zee, Chih-Te; Gallagher-Jones, Marcus; Martynowycz, Michael W; Rodriguez, Jose A; Gonen, Tamir

Analysis of Global and Site-Specific Radiation Damage in Cryo-EM

In: Structure, vol. 26, no. 5, pp. 759–766, 2018.

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Ma, Jinming; Lei, Hsiang-Ting; Reyes, Francis E.; Sanchez-Martinez, Silvia; Sarhan, Maen; Gonen, Tamir

Structural basis for substrate binding and specificity of a sodium/alanine symporter AgcS

bioRxiv, 2018.

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Liu, Yuxi; Gonen, Shane; Gonen, Tamir; Yeates, Todd O

Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system

In: Proc. Natl. Acad. Sci. U.S.A., vol. 115, no. 13, pp. 3362–3367, 2018.

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Lei, Hsiang-Ting; Ma, Jinming; Martinez, Silvia Sanchez; Gonen, Tamir

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state

bioRxiv, 2018.

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Guenther, Elizabeth L; Ge, Peng; Trinh, Hamilton; Sawaya, Michael R; Cascio, Duilio; Boyer, David R; Gonen, Tamir; Zhou, Hong Z; Eisenberg, David S

Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2

In: Nat. Struct. Mol. Biol., vol. 25, no. 4, pp. 311–319, 2018.

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Martynowycz, Michael W; Gonen, Tamir

From electron crystallography of 2D crystals to MicroED of 3D crystals

In: Curr Opin Colloid Interface Sci, vol. 34, pp. 9–16, 2018.

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Hughes, Michael P; Sawaya, Michael R; Boyer, David R; Goldschmidt, Lukasz; Rodriguez, Jose A; Cascio, Duilio; Chong, Lisa; Gonen, Tamir; Eisenberg, David S

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks

In: Science, vol. 359, no. 6376, pp. 698–701, 2018.

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Nannenga, Brent L; Gonen, Tamir

MicroED: a versatile cryoEM method for structure determination

In: Emerg Top Life Sci, vol. 2, no. 1, pp. 1–8, 2018.

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Hattne, Johan; Shi, Dan; Glynn, Calina; Zee, Chih-Te; Gallagher-Jones, Marcus; Martynowycz, Michael W.; Rodriguez, Jose A.; Gonen, Tamir

Analysis of global and site-specific radiation damage in cryo-EM

bioRxiv, 2018.

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Gallagher-Jones, Marcus; Glynn, Calina; Boyer, David R; Martynowycz, Michael W; Hernandez, Evelyn; Miao, Jennifer; Zee, Chih-Te; Novikova, Irina V; Goldschmidt, Lukasz; McFarlane, Heather T; Helguera, Gustavo F; Evans, James E; Sawaya, Michael R; Cascio, Duilio; Eisenberg, David S; Gonen, Tamir; Rodriguez, Jose A

Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp

In: Nat. Struct. Mol. Biol., vol. 25, no. 2, pp. 131–134, 2018.

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2017

Purdy, Michael D.; Shi, Dan; Chrustowicz, Jakub; Hattne, Johan; Gonen, Tamir; Yeager, Mark

MicroED Structures of HIV-1 Gag CTD-SP1 Reveal Binding Interactions with the Maturation Inhibitor Bevirimat

bioRxiv, 2017.

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Seidler, P M; Boyer, D R; Rodriguez, J A; Sawaya, M R; Cascio, D; Murray, K; Gonen, T; Eisenberg, D S

Structure-based inhibitors of tau aggregation

In: Nat Chem, vol. 10, no. 2, pp. 170–176, 2017.

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Liu, Yuxi; Gonen, Shane; Gonen, Tamir; Yeates, Todd O.

Near-Atomic Cryo-EM Imaging of a Small Protein Displayed on a Designed Scaffolding System

bioRxiv, 2017.

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Vergara, Sandra; Lukes, Dylan A; Martynowycz, Michael W; Santiago, Ulises; Plascencia-Villa, Germán; Weiss, Simon C; de la Cruz, Jason M; Black, David M; Alvarez, Marcos M; López-Lozano, Xochitl; Barnes, Christopher O; Lin, Guowu; Weissker, Hans-Christian; Whetten, Robert L; Gonen, Tamir; Yacaman, Miguel Jose; Calero, Guillermo

MicroED Structure of Au₁₄₆(p-MBA)₅₇ at Subatomic Resolution Reveals a Twinned FCC Cluster

In: J Phys Chem Lett, vol. 8, no. 22, pp. 5523–5530, 2017.

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Rodriguez, Jose A; Eisenberg, David S; Gonen, Tamir

Taking the measure of MicroED

In: Curr. Opin. Struct. Biol., vol. 46, pp. 79–86, 2017.

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Wright, Zoë V F; McCarthy, Stephen; Dickman, Rachel; Reyes, Francis E; Sanchez-Martinez, Silvia; Cryar, Adam; Kilford, Iian; Hall, Adrian; Takle, Andrew K; Topf, Maya; Gonen, Tamir; Thalassinos, Konstantinos; Tabor, Alethea B

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Naᵥ1.7

In: J. Am. Chem. Soc., vol. 139, no. 37, pp. 13063–13075, 2017.

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Liu, Shian; Hattne, Johan; Reyes, Francis E; Sanchez-Martinez, Silvia; de la Cruz, Jason M; Shi, Dan; Gonen, Tamir

Atomic resolution structure determination by the cryo-EM method MicroED

In: Protein Sci., vol. 26, no. 1, pp. 8–15, 2017.

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Hughes, Michael P.; Sawaya, Michael R.; Goldschmidt, Lukasz; Rodriguez, Jose A.; Cascio, Duilio; Gonen, Tamir; Eisenberg, David S.

Low-complexity domains adhere by reversible amyloid-like interactions between kinked β-sheets

bioRxiv, 2017.

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de la Cruz, M. Jason; Martynowycz, Michael; Hattne, Johan; Shi, Dan; Gonen, Tamir

A method to minimize condenser lens-induced hysteresis effects in a JEOL JEM-3200FSC microscope to enable stable cryoEM low-dose operations

bioRxiv 2017.

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Martynowycz, Michael W.; Glynn, Calina; Miao, Jennifer; de la Cruz, M. Jason; Hattne, Johan; Shi, Dan; Cascio, Duilio; Rodriguez, Jose; Gonen, Tamir

MicroED Structures from Micrometer Thick Protein Crystals

bioRxiv, 2017.

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Krotee, Pascal; Griner, Sarah L; Sawaya, Michael R; Cascio, Duilio; Rodriguez, Jose A; Shi, Dan; Philipp, Stephan; Murray, Kevin; Saelices, Lorena; Lee, Ji; Seidler, Paul; Glabe, Charles G; Jiang, Lin; Gonen, Tamir; Eisenberg, David S

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors

In: J. Biol. Chem., vol. 293, no. 8, pp. 2888–2902, 2017.

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de la Cruz, M. Jason; Hattne, Johan; Shi, Dan; Rodriguez, Jose A.; Reyes, Francis E.; Gonen, Tamir

Micro- and nanocrystal preparation for MicroED and XFEL serial crystallography by fragmentation of imperfect crystals

Nature Protocol Exchange 2017.

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de la Cruz, Jason M; Hattne, Johan; Shi, Dan; Seidler, Paul; Rodriguez, Jose; Reyes, Francis E; Sawaya, Michael R; Cascio, Duilio; Weiss, Simon C; Kim, Sun Kyung; Hinck, Cynthia S; Hinck, Andrew P; Calero, Guillermo; Eisenberg, David; Gonen, Tamir

Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED

In: Nat. Methods, vol. 14, no. 4, pp. 399–402, 2017.

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Krotee, Pascal; Rodriguez, Jose A; Sawaya, Michael R; Cascio, Duilio; Reyes, Francis E; Shi, Dan; Hattne, Johan; Nannenga, Brent L; Oskarsson, Marie E; Philipp, Stephan; Griner, Sarah; Jiang, Lin; Glabe, Charles G; Westermark, Gunilla T; Gonen, Tamir; Eisenberg, David S

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

In: Elife, vol. 6, 2017.

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Gonen, Tamir (Ed.)

Challenges in Structural Biology

HHMI Janelia Research Campus, 2017.

2016

Nannenga, Brent L; Gonen, Tamir

MicroED opens a new era for biological structure determination

In: Curr. Opin. Struct. Biol., vol. 40, pp. 128–135, 2016.

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Sawaya, Michael R; Rodriguez, Jose; Cascio, Duilio; Collazo, Michael J; Shi, Dan; Reyes, Francis E; Hattne, Johan; Gonen, Tamir; Eisenberg, David S

Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED

In: Proc. Natl. Acad. Sci. U.S.A., vol. 113, no. 40, pp. 11232–11236, 2016.

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Bale, Jacob B; Gonen, Shane; Liu, Yuxi; Sheffler, William; Ellis, Daniel; Thomas, Chantz; Cascio, Duilio; Yeates, Todd O; Gonen, Tamir; King, Neil P; Baker, David

Accurate design of megadalton-scale two-component icosahedral protein complexes

In: Science, vol. 353, no. 6297, pp. 389–394, 2016.

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Hsia, Yang; Bale, Jacob B; Gonen, Shane; Shi, Dan; Sheffler, William; Fong, Kimberly K; Nattermann, Una; Xu, Chunfu; Huang, Po‐Ssu.; Ravichandran, Rashmi; Yi, Sue; Davis, Trisha N; Gonen, Tamir; King, Neil P; Baker, David

Design of a hyperstable 60-subunit protein icosahedron

In: Nature, vol. 535, no. 7610, pp. 136–139, 2016.

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170 entries « 2 of 4 »