Tamir Gonen

Cover Art

Published Cover Art

2019 MicroED with the Falcon III direct electron detector. International Union of Crystallography Journal 

2018 The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination.

2017 Challenges in Structural Biology conference, Janelia Research Campus HHMI.

Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. Common fibrillary spines of amyloid-beta and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors. Journal of Biological Chemistry 293 (8): 2888 - 2902 (2018).

Liu Y., Gonen S., Gonen T. and Yeates TO. Near-Atomic Cryo-EM Imaging of a Small Protein Displayed on a Designed Scaffolding System. BioRxiv: https://doi.org/10.1101/212233 (2017).

Bale JB., Gonen S., Liu Y., Sheffler W., Ellis D., Thomas C, Cascio D., Yeates TO., Gonen T., King NP. and Baker D. Accurate design of megadalton-scale multi-component icosahedral protein complexes. Science 353 (6297): 389 - 394 (2016).

Gonen S., Akiyoshi B., Iadanza MG., Shi D., Duggan N., Biggins S. and Gonen T. The structure of purified kinetochores reveals multiple microtubule-attachment sites. Nature Structural and Molecular Biology 19 (9): 925 - 930 (2012).

Gonen T. The collection of high-resolution electron diffraction data. Methods in Molecular Biology - In Press (2012).

Gold MG., Reichow SL., O’Neill SE., Weisbrod CR., Langeberg LK., Bruce JE., Gonen T. and Scott JD. AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency. EMBO Molecular Medicine - 4: 15-26 (2012).

Reichow SL., Korotkov KV., Gonen M., Sun J., Delarosa J., Hol WGJ and Gonen T. The binding of cholera toxin to the periplasmic vestibule of the type II secretion channel. Channels - 5(3): 215 - 218 (2011).

Zheng H., Taraska J., Merz A. and Gonen T. The prototypical H+/galactose symporter GalP assembles into functional trimers. Journal of Molecular Biology 396: 593 - 601 (2010).

Zheng H., Olia A.S., Gonen M., Andrews S., Cingolani G. and Gonen T. A conformational switch in bacteriophage P22 portal protein primes genome injection. Molecular Cell 29: 376 - 383 (2008).

Gonen T., Cheng Y., Sliz P., Hiroaki Y., Fujiyoshi Y., Harrison SC. and Walz T. Lipid–protein interactions in double layered two dimensional crystals of AQP0. Nature 438: 633-638 (2005).

Gonen T., Cheng Y., Kistler J. and Walz T. Aquaporin-0 membrane junctions form upon proteolytic cleavage. Journal of Molecular Biology 342(4): 1337-45 (2004).

Gonen T., Donaldson PJ. and Kistler J. Galectin-3 – a new adhesion molecule in the lens. Investigative Ophthalmology and Visual Science 41: 199-203 (2000).


No associated publication.

Unpublished Art

Filbin ME., Vollmar BS., Shi D., Gonen T*. and Kieft JS*. HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. Nature Structural and Molecular Biology. *Co-Corresponding authors. 20 (2): 150 - 158 (2013).

King NP., Sheffler W., Sawaya MR., Vollmar BS., Sumida JP., Andre I., Gonen T., Yeates TO. and Baker D. Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science 336: 1171 - 1174 (2012).

Wisedchaisri G. and Gonen T. Fragment-based phase extension for three-dimensional structure determination of membrane proteins by electron crystallography. Structure - In Press (2011).

Jehle S., Vollmar B., Bardiaux B., Dove K., Rajagopal P., Gonen T*., Oschkinat H* and Klevit RE*. The N-terminal domain of αB-crystallin provides a conformational switch for multimerization and structural heterogeneity. *Co-Corresponding authors. Proceedings of the National Academy of Sciences 108: 6409 - 6414 (2011).

Reichow SL., Korotkov KV., Hol WGJ*. and Gonen T*. Structure of the cholera toxin secretion channel in its closed state. *Co-Corresponding authors. Nature Structural & Molecular Biology 17: 1226 - 1232 (2010).

Wisedchaisri G., Dranow DM., Lie TJ., Bonanno JB., Patskovsky Y., Ozyurt SA., Sauder JM., Almo SC., Wasserman SR., Burley SK., Leigh JA. and Gonen T. Structural underpinnings of nitrogen regulation by the prototypical nitrogen-responsive transcriptional factor NrpR. Structure 18: 1512 - 1521 (2010).

Reichow L.S. and Gonen T. Non-canonical binding of calmodulin to aquaporin-0: implications for channel regulation. Structure 16: 1389 - 1398 (2008).