CV for Tamir Gonen, Ph.D., MRSNZ

Investigator, Howard Hughes Medical Institute at UCLA

2005–2011Assistant Professor of Biochemistry, University of Washington, Seattle
2009–2011Howard Hughes Medical Institute Early Career Scientist
2011Associate Professor of Biochemistry (Tenured), University of Washington
2011–presentAffiliate Professor of Biochemistry, University of Washington, Seattle, WA
2011–2017Group Leader, HHMI, Janelia Research Campus, Ashburn VA
2017–PresentInvestigator, Howard Hughes Medical Institute.
2017–presentProfessor of Biological Chemistry and Physiology, David Geffen Medical School. UCLA, CA.

Honors

1996Deans List – Organic Chemistry, University of Auckland, New Zealand
1996Deans List – Inorganic Chemistry, University of Auckland, New Zealand
1997Center for Gene Technology Research Scholarship, University of Auckland, New Zealand
1997Deans List – Inorganic Chemistry, University of Auckland, New Zealand
1998Senior Prize in Biological Sciences, University of Auckland, New Zealand
1998First Class Honors in Biological Sciences, University of Auckland, New Zealand
1999University of Auckland Doctoral Scholarship, University of Auckland, New Zealand
2000Contestable Travel Fund Award, University of Auckland, New Zealand
2001Contestable Travel Fund Award, University of Auckland, New Zealand
2009American Diabetes Association Career Development Award
2009Howard Hughes Medical Institute Early Career Scientist
2010New Investigator Science in Medicine Lecture
2012Member, The Royal Society of New Zealand
2017Investigator, Howard Hughes Medical Institute
2018Chair elect, Biophysical Society cryoEM subgroup

Publications in Pubmed

Publications

113 entries « 2 of 3 »

2015

Gonen, Shane; DiMaio, Frank; Gonen, Tamir; Baker, David

Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces Journal Article

Science, 348 (6241), pp. 1365–1368, 2015.

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2014

Huang, Po-Ssu; Oberdorfer, Gustav; Xu, Chunfu; Pei, Xue Y; Nannenga, Brent L; Rogers, Joseph M; DiMaio, Frank; Gonen, Tamir; Luisi, Ben; Baker, David

High thermodynamic stability of parametrically designed helical bundles Journal Article

Science, 346 (6208), pp. 481–485, 2014.

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Nannenga, Brent L; Shi, Dan; Hattne, Johan; Reyes, Francis E; Gonen, Tamir

Structure of catalase determined by MicroED Journal Article

Elife, 3 , pp. e03600, 2014.

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Russell, Alistair B; Wexler, Aaron G; Harding, Brittany N; Whitney, John C; Bohn, Alan J; Goo, Young Ah; Tran, Bao Q; Barry, Natasha A; Zheng, Hongjin; Peterson, Brook S; Chou, Seemay; Gonen, Tamir; Goodlett, David R; Goodman, Andrew L; Mougous, Joseph D

A type VI Secretion-Related Pathway in Bacteroidetes Mediates Interbacterial Antagonism Journal Article

Cell Host Microbe, 16 (2), pp. 227–236, 2014.

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Wisedchaisri, Goragot; Park, Min-Sun; Iadanza, Matthew G; Zheng, Hongjin; Gonen, Tamir

Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE Journal Article

Nat Commun, 5 , pp. 4521, 2014.

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Nannenga, Brent L; Shi, Dan; Leslie, Andrew G W; Gonen, Tamir

High-resolution structure determination by continuous-rotation data collection in MicroED Journal Article

Nat. Methods, 11 (9), pp. 927–930, 2014.

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Nannenga, Brent L; Gonen, Tamir

Protein structure determination by MicroED Journal Article

Curr. Opin. Struct. Biol., 27 , pp. 24–31, 2014.

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Gonen, Tamir; Waksman, Gabriel

Editorial overview: Membranes: recent methods in the study of membrane protein structure Journal Article

Curr. Opin. Struct. Biol., 27 , pp. iv-v, 2014.

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King, Neil P; Bale, Jacob B; Sheffler, William; McNamara, Dan E; Gonen, Shane; Gonen, Tamir; Yeates, Todd O; Baker, David

Accurate design of co-assembling multi-component protein nanomaterials Journal Article

Nature, 510 (7503), pp. 103–108, 2014.

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Iadanza, Matthew G; Gonen, Tamir

A suite of software for processing MicroED data of extremely small protein crystals Journal Article

J Appl Crystallogr, 47 (Pt 3), pp. 1140–1145, 2014.

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Anderson, Thomas M; Clay, Mary C; Cioffi, Alexander G; Diaz, Katrina A; Hisao, Grant S; Tuttle, Marcus D; Nieuwkoop, Andrew J; Comellas, Gemma ; Maryum, Nashrah ; Wang, Shu ; Uno, Brice E; Wildeman, Erin L; Gonen, Tamir ; Rienstra, Chad M; Burke, Martin D

Amphotericin forms an extramembranous and fungicidal sterol sponge Journal Article

Nat. Chem. Biol., 10 (5), pp. 400–406, 2014.

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2013

Shi, Dan; Nannenga, Brent L; Iadanza, Matthew G; Gonen, Tamir

Three-dimensional electron crystallography of protein microcrystals Journal Article

Elife, 2 , pp. e01345, 2013.

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Smith, Donelson F; Reichow, Steve L; Esseltine, Jessica L; Shi, Dan; Langeberg, Lorene K; Scott, John D; Gonen, Tamir

Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation Journal Article

Elife, 2 , pp. e01319, 2013.

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Gold, Matthew G; Gonen, Tamir; Scott, John D

Local cAMP signaling in disease at a glance Journal Article

J. Cell. Sci., 126 (Pt 20), pp. 4537–4543, 2013.

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Reichow, Stephen ; Gonen, Tamir

Dynamic Modulation of Water Permeability in the Lens Aquaporin-0 Inproceedings

Proceedings of Microscopy & Microanalysis, pp. 50–51, 2013.

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Silverman, Julie M; Agnello, Danielle M; Zheng, Hongjin; Andrews, Benjamin T; Li, Mo; Catalano, Carlos E; Gonen, Tamir; Mougous, Joseph D

Haemolysin Coregulated Protein Is an Exported Receptor and Chaperone of Type VI Secretion Substrates Journal Article

Mol. Cell, 51 (5), pp. 584–593, 2013.

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Reichow, Steve L; Clemens, Daniel M; Freites, Alfredo J; Nemeth-Cahalan, Karin L; Heyden, Matthias; Tobias, Douglas J; Hall, James E; Gonen, Tamir

Allosteric mechanism of water-channel gating by Ca²⁺-calmodulin Journal Article

Nat. Struct. Mol. Biol., 20 (9), pp. 1085–1092, 2013.

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Zheng, Hongjin; Wisedchaisri, Goragot; Gonen, Tamir

Crystal structure of a nitrate/nitrite exchanger Journal Article

Nature, 497 (7451), pp. 647–651, 2013.

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Nannenga, Brent L; Iadanza, Matthew G; Vollmar, Breanna S; Gonen, Tamir

Overview of Electron Crystallography of Membrane Proteins: Crystallization and Screening Strategies Using Negative Stain Electron Microscopy Journal Article

Curr Protoc Protein Sci, 72 (1), pp. 17.15.1–17.15.11, 2013.

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Shi, Liang; Zheng, Hongjin; Zheng, Hui; Borkowski, Brian A; Shi, Dan; Gonen, Tamir; Jiang, Qiu-Xing

Voltage sensor ring in a native structure of a membrane-embedded potassium channel Journal Article

Proc. Natl. Acad. Sci. U.S.A., 110 (9), pp. 3369–3374, 2013, (Retracted).

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2012

Filbin, Megan E; Vollmar, Breanna S; Shi, Dan; Gonen, Tamir; Kieft, Jeffrey S

HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation Journal Article

Nat. Struct. Mol. Biol., 20 (2), pp. 150–158, 2012.

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Wisedchaisri, Goragot; Gonen, Tamir

Phasing Electron Diffraction Data by Molecular Replacement: Strategy for Structure Determination and Refinement Book Chapter

Electron Crystallography of Soluble and Membrane Proteins, 955 , Chapter 14, pp. 243–272, 2012.

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Gonen, Tamir

The Collection of High-Resolution Electron Diffraction Data Book Chapter

Electron Crystallography of Soluble and Membrane Proteins, 955 , Chapter 9, pp. 153–169, 2012.

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Stokes, David L; Ubarretxena-Belandia, Iban; Gonen, Tamir; Engel, Andreas

High-Throughput Methods for Electron Crystallography Book Chapter

Electron Crystallography of Soluble and Membrane Proteins, 955 , Chapter 15, pp. 273–296, 2012.

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Umbreit, Neil T; Gestaut, Daniel R; Tien, Jerry F; Vollmar, Breanna S; Gonen, Tamir ; Asbury, Charles L; Davis, Trisha N

The Ndc80 kinetochore complex directly modulates microtubule dynamics Journal Article

Proc. Natl. Acad. Sci. U.S.A., 109 (40), pp. 16113–16118, 2012.

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Gonen, Shane; Akiyoshi, Bungo; Iadanza, Matthew G; Shi, Dan; Duggan, Nicole; Biggins, Sue; Gonen, Tamir

The structure of purified kinetochores reveals multiple microtubule-attachment sites Journal Article

Nat. Struct. Mol. Biol., 19 (9), pp. 925–929, 2012.

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Gonen, Tamir; Waksman, Gabriel

Recent progress in membrane protein structures and investigation methods Journal Article

Curr. Opin. Struct. Biol., 22 (4), pp. 467–468, 2012.

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Jiang, Qiu-Xing; Gonen, Tamir

The influence of lipids on voltage-gated ion channels Journal Article

Curr. Opin. Struct. Biol., 22 (4), pp. 529–536, 2012.

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King, Neil P; Sheffler, William; Sawaya, Michael R; Vollmar, Breanna S; Sumida, John P; André, Ingemar; Gonen, Tamir; Yeates, Todd O; Baker, David

Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy Journal Article

Science, 336 (6085), pp. 1171–1174, 2012.

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2011

Lo, Sheng-Ying; Brett, Christopher L; Plemel, Rachael L; Vignali, Marissa; Fields, Stanley; Gonen, Tamir; Merz, Alexey J

Intrinsic tethering activity of endosomal Rab proteins Journal Article

Nat. Struct. Mol. Biol., 19 (1), pp. 40–47, 2011.

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Gold, Matthew G; Reichow, Steve L; O'Neill, Susan E; Weisbrod, Chad R; Langeberg, Lorene K; Bruce, James E; Gonen, Tamir; Scott, John D

AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency Journal Article

EMBO Mol Med, 4 (1), pp. 15–26, 2011.

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Wisedchaisri, Goragot; Reichow, Steve L; Gonen, Tamir

Advances in Structural and Functional Analysis of Membrane Proteins by Electron Crystallography Journal Article

Structure, 19 (10), pp. 1381–1393, 2011.

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Korotkov, Konstantin V; Gonen, Tamir; Hol, Wim G J

Secretins: dynamic channels for protein transport across membranes Journal Article

Trends Biochem. Sci., 36 (8), pp. 433–443, 2011.

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Wisedchaisri, Goragot; Gonen, Tamir

Fragment-Based Phase Extension for Three-Dimensional Structure Determination of Membrane Proteins by Electron Crystallography Journal Article

Structure, 19 (7), pp. 976–987, 2011.

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Reichow, Steve L; Korotkov, Konstantin V; Gonen, Melissa; Sun, Ji; Delarosa, Jaclyn R; Hol, Wim G J; Gonen, Tamir

The binding of cholera toxin to the periplasmic vestibule of the type II secretion channel Journal Article

Channels (Austin), 5 (3), pp. 215–218, 2011.

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Jehle, Stefan; Vollmar, Breanna S; Bardiaux, Benjamin; Dove, Katja K; Rajagopal, Ponni; Gonen, Tamir; Oschkinat, Hartmut; Klevit, Rachel E

N-terminal domain of αB-crystallin provides a conformational switch for multimerization and structural heterogeneity Journal Article

Proc. Natl. Acad. Sci. U.S.A., 108 (16), pp. 6409–6414, 2011.

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Budzinski, Kristi L; Sgro, Allyson E; Fujimoto, Bryant S; Gadd, Jennifer C; Shuart, Noah G; Gonen, Tamir; Bajjaleih, Sandra M; Chiu, Daniel T

Synaptosomes as a Platform for Loading Nanoparticles into Synaptic Vesicles Journal Article

ACS Chem Neurosci, 2 (5), pp. 236–241, 2011.

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2010

Akiyoshi, Bungo ; Sarangapani, Krishna K; Powers, Andrew F; Nelson, Christian R; Reichow, Steve L; Arellano-Santoyo, Hugo ; Gonen, Tamir ; Ranish, Jeffrey A; Asbury, Charles L; Biggins, Sue

Tension directly stabilizes reconstituted kinetochore-microtubule attachments Journal Article

Nature, 468 (7323), pp. 576–579, 2010.

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Wisedchaisri, Goragot; Dranow, David M; Lie, Thomas J; Bonanno, Jeffrey B; Patskovsky, Yury; Ozyurt, Sinem A; Sauder, Michael J; Almo, Steven C; Wasserman, Stephen R; Burley, Stephen K; Leigh, John A; Gonen, Tamir

Structural Underpinnings of Nitrogen Regulation by the Prototypical Nitrogen-Responsive Transcriptional Factor NrpR Journal Article

Structure, 18 (11), pp. 1512–1521, 2010.

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Reichow, Steve L; Korotkov, Konstantin V; Hol, Wim G J; Gonen, Tamir

Structure of the cholera toxin secretion channel in its closed state Journal Article

Nat. Struct. Mol. Biol., 17 (10), pp. 1226–1232, 2010.

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Sedlak, Ruth Hall; Hnilova, Marketa; Gachelet, Eliora; Przybyla, Lyralynne; Dranow, David; Gonen, Tamir; Sarikaya, Mehmet; Tamerler, Candan; Traxler, Beth

An Engineered DNA-binding Protein Self-assembles Metallic Nanostructures Journal Article

Chembiochem, 11 (15), pp. 2108–2112, 2010.

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Sanowar, Sarah; Singh, Pragya; Pfuetzner, Richard A; André, Ingemar; Zheng, Hongjin; Spreter, Thomas; Strynadka, Natalie C J; Gonen, Tamir; Baker, David; Goodlett, David R; Miller, Samuel I

Interactions of the Transmembrane Polymeric Rings of the Salmonella enterica Serovar Typhimurium type III Secretion System Journal Article

MBio, 1 (3), pp. e00158-10, 2010.

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Tien, Jerry F; Umbreit, Neil T; Gestaut, Daniel R; Franck, Andrew D; Cooper, Jeremy; Wordeman, Linda; Gonen, Tamir; Asbury, Charles L; Davis, Trisha N

Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B Journal Article

J. Cell Biol., 189 (4), pp. 713–723, 2010.

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Zheng, Hongjin; Taraska, Justin; Merz, Alexey J; Gonen, Tamir

The prototypical H⁺/Galactose Symporter GalP Assembles into Functional Trimers Journal Article

J. Mol. Biol., 396 (3), pp. 593–601, 2010.

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2009

Reichow, Steve L; Gonen, Tamir

Lipid-protein interactions probed by electron crystallography Journal Article

Curr. Opin. Struct. Biol., 19 (5), pp. 560–565, 2009.

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2008

Reichow, Steve L; Gonen, Tamir

Noncanonical Binding of Calmodulin to Aquaporin-0: Implications for Channel Regulation Journal Article

Structure, 16 (9), pp. 1389–1398, 2008.

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Zheng, Hongjin; Wisedchaisri, Goragot; Gonen, Tamir

Single Particle Electron Cryomicroscopy of Bacteriophage P22 Portal Protein Complexes Journal Article

Microscopy and Microanalysis, 14 (S2), pp. 1572–1573, 2008.

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Hite, Richard K; Gonen, Tamir; Harrison, Stephen C; Walz, Thomas

Interactions of lipids with aquaporin-0 and other membrane proteins Journal Article

Pflugers Arch., 456 (4), pp. 651–661, 2008.

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Andrews, Simeon ; Reichow, Steve L; Gonen, Tamir

Electron Crystallography of Aquaporins Journal Article

IUBMB Life, 60 (7), pp. 430–436, 2008.

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Engel, Andreas; Fujiyoshi, Yoshinori; Gonen, Tamir; Walz, Thomas

Junction-forming aquaporins Journal Article

Curr. Opin. Struct. Biol., 18 (2), pp. 229–235, 2008.

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113 entries « 2 of 3 »